Contents
Vol 6, Issue 301
Contents
Research Articles
- Regulation of Epithelial Morphogenesis by the G Protein–Coupled Receptor Mist and Its Ligand Fog
The GPCR Mist is required for Fog-induced contractility in cells and acts parallel to Fog in Drosophila epithelial morphogenesis.
- The Ability of Sos1 to Oligomerize the Adaptor Protein LAT Is Separable from Its Guanine Nucleotide Exchange Activity in Vivo
Thymocyte development requires that Sos1 acts both as a guanine nucleotide exchange factor and as a scaffold to cluster adaptor proteins.
Podcast
- Science Signaling Podcast: 12 November 2013
The G protein–coupled receptor Mist is the receptor for Fog, a secreted factor that drives gastrulation in fruit fly embryos.
Editors' Choice
- p21: Protector of Progenitor Pools
The cell cycle inhibitor p21 maintains neural stem cell pools through a cell cycle–independent mechanism.
- Dissecting Hippo Interactions
A proteomics approach for protein-protein interactions reveals new components of a conserved cell signaling pathway.
- Making More Inhibitory Connections
NPAS4, an activity-dependent transcription factor, increases the number of inhibitory synapses to contribute to neuronal synaptic plasticity.
- Thrombosis Prevention Without Bleeding Extension
Selectively inhibiting outside-in signaling prevents platelet spreading and prevents thrombosis without increasing bleeding time.
- Mitochondrial Fusion and Heart Development
Interrupting mitochondrial fusion inhibits cardiac differentiation by dysregulating a specific cell signaling pathway.
- Lighting Up Immunity
Diurnal regulation of an immune cell lineage in the intestine protects against inflammatory disease in mice.
