Contents
Vol 6, Issue 303
Contents
Research Articles
- Diacylglycerol Kinase ζ Limits the Generation of Natural Regulatory T Cells
Increasing the activation of extracellular signal–regulated kinase promotes the generation of natural regulatory T cells.
- The ζ Isoform of Diacylglycerol Kinase Plays a Predominant Role in Regulatory T Cell Development and TCR-Mediated Ras Signaling
Despite its relatively low abundance, DGKζ exerts a major inhibitory effect on T cell receptor signaling.
Podcast
- Science Signaling Podcast: 26 November 2013
Differential catalytic activities of the α and ζ isoforms of diacylglycerol kinase contribute to differences in the effects of these enzymes on natural regulatory T cell development.
Editors' Choice
- Shocking Response
Macrophages responding to an RNA-binding protein released in response to shock trigger systemic inflammation.
- Restricting Bone Metastasis
Signaling by the growth factor TGF-β2 prevents the growth of squamous carcinoma that metastasizes to the bone.
- RAR Scars Bone Marrow
A genetic mouse model of the bone disease myelofibrosis indicates that excessive retinoic acid signaling may be responsible.
- Autophagy for Better Heart Health
Decreasing the activity of the Hippo pathway kinase Mst1 to promote autophagy could be used to treat heart failure.
- An Addictive Switch
A single exposure to cocaine induces a switch in NMDA receptor subunits.
