Contents
Vol 6, Issue 304
Contents
Research Articles
- HES1 Is a Master Regulator of Glucocorticoid Receptor–Dependent Gene Expression
A transcription factor that regulates developmental events also suppresses transcriptional responses to stress in adult organisms.
- Lysine Methylation Promotes VEGFR-2 Activation and Angiogenesis
Preventing the methylation of VEGFR-2 could attenuate pathological angiogenesis in cancer.
- PLC-γ and PI3K Link Cytokines to ERK Activation in Hematopoietic Cells with Normal and Oncogenic Kras
Targeting signaling pathways upstream of oncogenic Ras may have therapeutic benefit in the treatment of leukemia.
Editors' Choice
- Snuffing Out Marijuana Inflammation
Inhibition of COX2 may prevent the memory impairment caused by the active ingredient in marijuana.
- Cholesterol and Cancer
The activity of a specific metabolite of cholesterol may help explain why obesity is a risk factor for breast cancer.
- Hormones in Repair and Resistance
Radiotherapy resistance in prostate cancer is promoted by androgen receptor-stimulated transcription of DNA repair genes.
- It Takes a Few
Induction of long-term potentiation in a few dendritic spines signals to the nucleus to activate transcription factors.
- Neuronal Activity and Dendrite Development
High-acuity sensory function may be achieved by the tuning of subcellular polarity to sources of high sensory activity.
- Adrenergic Regulation of Antibodies
Primed B cells stimulated through the β2-adrenergic receptor release exosomes that enhance IgE production by recipient B cells.