Contents

Contents

• Research Articles

  • HES1 Is a Master Regulator of Glucocorticoid Receptor–Dependent Gene Expression

    By Javier R. Revollo, Robert H. Oakley, Nick Z. Lu, Mahita Kadmiel, Maheer Gandhavadi, John A. Cidlowski

    Science Signaling03 Dec 2013 : ra103 Full AccessRestricted Access

    A transcription factor that regulates developmental events also suppresses transcriptional responses to stress in adult organisms.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF

  • Lysine Methylation Promotes VEGFR-2 Activation and Angiogenesis

    By Edward J. Hartsough, Rosana D. Meyer, Vipul Chitalia, Yan Jiang, Victor E. Marquez, Irina V. Zhdanova, Janice Weinberg, Catherine E. Costello, Nader Rahimi

    Science Signaling03 Dec 2013 : ra104 Full AccessRestricted Access

    Preventing the methylation of VEGFR-2 could attenuate pathological angiogenesis in cancer.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF

  • PLC-γ and PI3K Link Cytokines to ERK Activation in Hematopoietic Cells with Normal and Oncogenic Kras

    By Ernesto Diaz-Flores, Hana Goldschmidt, Philippe Depeille, Victor Ng, Jon Akutagawa, Kimberly Krisman, Michael Crone, Michael R. Burgess, Olusegun Williams, Benjamin Houseman, Kevan Shokat, Deepak Sampath, Gideon Bollag, Jeroen P. Roose, Benjamin S. Braun, Kevin Shannon

    Science Signaling03 Dec 2013 : ra105 Full AccessRestricted Access

    Targeting signaling pathways upstream of oncogenic Ras may have therapeutic benefit in the treatment of leukemia.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF

• Editors' Choice

  • Snuffing Out Marijuana Inflammation

    By Jason D. Berndt

    Science Signaling03 Dec 2013 : ec291 Full AccessRestricted Access

    Inhibition of COX2 may prevent the memory impairment caused by the active ingredient in marijuana.

    • Abstract

  • Cholesterol and Cancer

    By Paula A. Kiberstis

    Science Signaling03 Dec 2013 : ec292 Full AccessRestricted Access

    The activity of a specific metabolite of cholesterol may help explain why obesity is a risk factor for breast cancer.

    • Abstract

  • Hormones in Repair and Resistance

    By Leslie K. Ferrarelli

    Science Signaling03 Dec 2013 : ec293 Full AccessRestricted Access

    Radiotherapy resistance in prostate cancer is promoted by androgen receptor-stimulated transcription of DNA repair genes.

    • Abstract

  • It Takes a Few

    By Stella M. Hurtley

    Science Signaling03 Dec 2013 : ec294 Full AccessRestricted Access

    Induction of long-term potentiation in a few dendritic spines signals to the nucleus to activate transcription factors.

    • Abstract

  • Neuronal Activity and Dendrite Development

    By Pamela J. Hines

    Science Signaling03 Dec 2013 : ec295 Full AccessRestricted Access

    High-acuity sensory function may be achieved by the tuning of subcellular polarity to sources of high sensory activity.

    • Abstract

  • Adrenergic Regulation of Antibodies

    By John F. Foley

    Science Signaling03 Dec 2013 : ec296 Full AccessRestricted Access

    Primed B cells stimulated through the β₂-adrenergic receptor release exosomes that enhance IgE production by recipient B cells.

    • Abstract