Research ArticleCell Biology

Lysine Methylation Promotes VEGFR-2 Activation and Angiogenesis

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Science Signaling  03 Dec 2013:
Vol. 6, Issue 304, pp. ra104
DOI: 10.1126/scisignal.2004289

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Activating Angiogenesis

The vascular endothelial growth factor receptor-2 (VEGFR-2) promotes the formation of new blood vessels in a process called angiogenesis. Hartsough et al. identified a key lysine residue in VEGFR-2 that underwent methylation, a posttranslational modification that enhanced the activity of this receptor. Cells expressing a form of VEGFR-2 that could not be methylated at this residue formed smaller tumors in mice, and developing zebrafish expressing this mutant form of VEGFR-2 showed reduced blood vessel formation. Thus, preventing the methylation of VEGFR-2 could be a strategy to limit angiogenesis and thus the growth of tumors.

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