17 December 2013
Vol 6, Issue 306

About The Cover

Cover image expansion

Online Cover This week features a Research Article that combines knowledge of protein structure and abundance to predict competition for binding a common partner protein. This week's issue also includes an Editorial Guide with vignettes from researchers in memory of Tony Pawson, who identified that such modular protein-protein interactions regulate signal transduction. The image shows CRAF (red) outcompeting GAP (yellow) for binding to Ras (blue). [Image: Chris Bickel/AAAS]