Contents
Vol 6, Issue 306
Contents
Editorial Guide
- Death of a Titan
Science Signaling remembers Tony Pawson, a leader in cell signaling.
Research Articles
- PLCε, PKD1, and SSH1L Transduce RhoA Signaling to Protect Mitochondria from Oxidative Stress in the Heart
Protecting mitochondria from oxidative stress–induced signals protects the heart.
- Integration of Protein Abundance and Structure Data Reveals Competition in the ErbB Signaling Network
Competition among mutually exclusive binding partners contributes to context-dependent differences in signaling responses.
- Activation of the Transcription Factor c-Maf in T Cells Is Dependent on the CARMA1-IKKβ Signaling Cascade
Components of the NF-κB pathway promote the differentiation of T cells that are critical for antibody production by B cells.
Research Resource
- Deep Sequencing and High-Resolution Imaging Reveal Compartment-Specific Localization of Bdnf mRNA in Hippocampal Neurons
High-resolution analysis reveals that Bdnf transcripts are weakly but selectively localized to the cell body, not dendrites, of hippocampal neurons.
Editors' Choice
- Foiling Fibrosis
Preventing αv integrin from activating TGF-β1 could be a therapeutic strategy for treating fibrotic diseases.
- TAMpering with the Tumor Immune Response
Inhibiting neuropilin 1 in macrophages may block their immunosuppressive reprogramming in the tumor microenvironment.
- Opioid-Related Peptides for Treating Anxiety
Female mice with age-related adrenal hyperplasia are less anxious because of interplay between opioid and glucocorticoid signaling.
- Atg9 Induces JNK-Mediated Stress Signaling
Atg9 promotes oxidative stress–induced autophagy independently of its role in starvation-induced autophagy.
- EMRE Emerges
A final but essential protein component involved in maintaining mitochondrial calcium levels is discovered.
- EPO via Total Synthesis
Chemical synthesis of a glycoprotein hormone provides a sample uniformly substituted with specific sugar chains.
Errata
- A Correction to the Editors' Choice Summary Titled “Not So Different After All” by Annalisa M. VanHook
There were typographical errors in two protein names.
- A Correction to the Editors' Choice Summary Titled “Keeping Bone Where Bone Belongs” by Leslie K. Ferrarelli
Activating mutations in GNAS were mistakenly attributed as causing fibrodysplasia ossificans progressiva, instead of fibrous dysplasia.
