Research ArticleCardiovascular Biology

PLCε, PKD1, and SSH1L Transduce RhoA Signaling to Protect Mitochondria from Oxidative Stress in the Heart

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Science Signaling  17 Dec 2013:
Vol. 6, Issue 306, pp. ra108
DOI: 10.1126/scisignal.2004405

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Protecting the Heart from Oxidative Stress

Myocardial ischemia triggers the release of the sphingolipid sphingosine 1-phosphate (S1P), which activates the small guanosine triphosphatase RhoA. Both S1P and RhoA have been implicated in signaling that protects the heart from damage during myocardial ischemia. Xiang et al. delineated the signaling pathway downstream of S1P and RhoA that preserved mitochondrial integrity and prevented activation of a mitochondria-mediated cell death pathway in response to the oxidative stress that can occur during myocardial ischemia. Thus, enhancing signaling through this pathway could help to limit the cellular damage that results from myocardial ischemia and reperfusion.

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