Activation of the Transcription Factor c-Maf in T Cells Is Dependent on the CARMA1-IKKβ Signaling Cascade

Marzenna Blonska; Donghyun Joo; Roza I. Nurieva; Xueqiang Zhao; Paul Chiao; Shao-Cong Sun; Chen Dong; Xin Lin

doi:10.1126/scisignal.2004273

Research ArticleImmunology

Activation of the Transcription Factor c-Maf in T Cells Is Dependent on the CARMA1-IKKβ Signaling Cascade

Marzenna Blonska¹,²,
Donghyun Joo¹,³,
Roza I. Nurieva²,⁴,
Xueqiang Zhao¹,²,
Paul Chiao¹,²,³,
Shao-Cong Sun²,³,⁴,
Chen Dong²,⁴, and
Xin Lin¹,²,³,⁴,*

¹Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
²Center for Inflammation and Cancer, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
³Cancer Biology Program, The University of Texas Graduate School of Biomedical Sciences, Houston, TX 77030, USA.
⁴Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

↵*Corresponding author. E-mail: xllin{at}mdanderson.org

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Science Signaling 17 Dec 2013:
Vol. 6, Issue 306, pp. ra110
DOI: 10.1126/scisignal.2004273

Marzenna Blonska

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Donghyun Joo

Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.Cancer Biology Program, The University of Texas Graduate School of Biomedical Sciences, Houston, TX 77030, USA.

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Roza I. Nurieva

Center for Inflammation and Cancer, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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Xueqiang Zhao

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Paul Chiao

Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.Center for Inflammation and Cancer, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.Cancer Biology Program, The University of Texas Graduate School of Biomedical Sciences, Houston, TX 77030, USA.

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Shao-Cong Sun

Center for Inflammation and Cancer, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.Cancer Biology Program, The University of Texas Graduate School of Biomedical Sciences, Houston, TX 77030, USA.Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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Chen Dong

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Xin Lin

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For correspondence: xllin@mdanderson.org

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Activation of the Transcription Factor c-Maf in T Cells Is Dependent on the CARMA1-IKKβ Signaling Cascade

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