Activation of the Transcription Factor c-Maf in T Cells Is Dependent on the CARMA1-IKKβ Signaling Cascade

Marzenna Blonska; Donghyun Joo; Roza I. Nurieva; Xueqiang Zhao; Paul Chiao; Shao-Cong Sun; Chen Dong; Xin Lin

doi:10.1126/scisignal.2004273

Research ArticleImmunology

Activation of the Transcription Factor c-Maf in T Cells Is Dependent on the CARMA1-IKKβ Signaling Cascade

Marzenna Blonska¹,²,
Donghyun Joo¹,³,
Roza I. Nurieva²,⁴,
Xueqiang Zhao¹,²,
Paul Chiao¹,²,³,
Shao-Cong Sun²,³,⁴,
Chen Dong²,⁴, and
Xin Lin¹,²,³,⁴,*

¹Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
²Center for Inflammation and Cancer, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
³Cancer Biology Program, The University of Texas Graduate School of Biomedical Sciences, Houston, TX 77030, USA.
⁴Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

↵*Corresponding author. E-mail: xllin{at}mdanderson.org

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Science Signaling 17 Dec 2013:
Vol. 6, Issue 306, pp. ra110
DOI: 10.1126/scisignal.2004273

Marzenna Blonska

1Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

2Center for Inflammation and Cancer, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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Donghyun Joo

1Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

3Cancer Biology Program, The University of Texas Graduate School of Biomedical Sciences, Houston, TX 77030, USA.

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Roza I. Nurieva

2Center for Inflammation and Cancer, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

4Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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Xueqiang Zhao

1Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

2Center for Inflammation and Cancer, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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Paul Chiao

1Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

2Center for Inflammation and Cancer, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

3Cancer Biology Program, The University of Texas Graduate School of Biomedical Sciences, Houston, TX 77030, USA.

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Shao-Cong Sun

2Center for Inflammation and Cancer, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

3Cancer Biology Program, The University of Texas Graduate School of Biomedical Sciences, Houston, TX 77030, USA.

4Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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Chen Dong

2Center for Inflammation and Cancer, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

4Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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Xin Lin

1Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

2Center for Inflammation and Cancer, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

3Cancer Biology Program, The University of Texas Graduate School of Biomedical Sciences, Houston, TX 77030, USA.

4Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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For correspondence: xllin@mdanderson.org

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Activation of the Transcription Factor c-Maf in T Cells Is Dependent on the CARMA1-IKKβ Signaling Cascade

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