Contents
Vol 7, Issue 307
Contents
Editorial Guide
- 2013: Signaling Breakthroughs of the Year
The year’s highlights include structural insights into signaling proteins, advances in understanding signaling dynamics, and advances in methods for studying cellular regulatory phenomena.
Research Articles
- A Ligand-Independent VEGFR2 Signaling Pathway Limits Angiogenic Responses in Diabetes
Hyperglycemia restricts the formation of new blood vessels by preventing VEGFR2 from responding to its angiogenic ligand VEGF.
- TRAF6 Stimulates the Tumor-Promoting Effects of TGFβ Type I Receptor Through Polyubiquitination and Activation of Presenilin 1
Preventing the cleavage of the TGFβ type I receptor by presenilin 1 could limit prostate tumor growth.
- The Ubiquitin-Specific Protease USP15 Promotes RIG-I–Mediated Antiviral Signaling by Deubiquitylating TRIM25
A deubiquitylating enzyme prolongs the innate immune response to viruses by preventing degradation of the ubiquitin E3 ligase TRIM25.
Perspective
- Inhibiting the Response to VEGF in Diabetes
Hyperglycemia dampens endothelial cell responses to VEGF by triggering receptor activation and degradation in a ligand-independent manner.
Podcast
- Science Signaling Podcast: 7 January 2014
A deubiquitinase promotes interferon production to prolong the antiviral response.
Editors' Choice
- From Milk to Memory
Absence of an inflammatory cytokine in maternal milk enhances hippocampal development and cognitive function in offspring.
- Counteracting Cannabis
The universal precursor of steroid hormones acts as a negative allosteric modulator of cannabinoid receptors.
- G Structures
The structure of a human serotonin receptor was solved using a free-electron laser to analyze microcrystals.
- Playing Hide and Seek
Tumor cells become resistant to targeted therapies by eliminating the gene encoding the drug target from extrachromosomal DNA.
- More from mTOR
A drug in clinical use for other disorders delays progression of an untreatable mitochondrial disease in knockout mice.
- From Stimulating Regeneration to Provoking Fibrosis
A switch in receptor balance switches liver endothelial cells from promoting regeneration to stimulating fibrosis.
