Contents

Contents

• Editorial Guide

  • 2013: Signaling Breakthroughs of the Year

    By Jason D. Berndt, Nancy R. Gough

    Science Signaling07 Jan 2014 : eg1 Full AccessRestricted Access

    The year’s highlights include structural insights into signaling proteins, advances in understanding signaling dynamics, and advances in methods for studying cellular regulatory phenomena.

    • Abstract
    • Full Text
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• Research Articles

  • A Ligand-Independent VEGFR2 Signaling Pathway Limits Angiogenic Responses in Diabetes

    By Carmen M. Warren, Safiyyah Ziyad, Anaïs Briot, Aaron Der, M. Luisa Iruela-Arispe

    Science Signaling07 Jan 2014 : ra1 Full AccessRestricted Access

    Hyperglycemia restricts the formation of new blood vessels by preventing VEGFR2 from responding to its angiogenic ligand VEGF.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF
    • Supplementary Materials

  • TRAF6 Stimulates the Tumor-Promoting Effects of TGFβ Type I Receptor Through Polyubiquitination and Activation of Presenilin 1

    By Shyam Kumar Gudey, Reshma Sundar, Yabing Mu, Anders Wallenius, Guangxiang Zang, Anders Bergh, Carl-Henrik Heldin, Marene Landström

    Science Signaling07 Jan 2014 : ra2 Full AccessRestricted Access

    Preventing the cleavage of the TGFβ type I receptor by presenilin 1 could limit prostate tumor growth.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF
    • Supplementary Materials

  • The Ubiquitin-Specific Protease USP15 Promotes RIG-I–Mediated Antiviral Signaling by Deubiquitylating TRIM25

    By Eva-Katharina Pauli, Ying Kai Chan, Meredith E. Davis, Sebastian Gableske, May K. Wang, Katharina F. Feister, Michaela U. Gack

    Science Signaling07 Jan 2014 : ra3 Full AccessRestricted Access

    A deubiquitylating enzyme prolongs the innate immune response to viruses by preventing degradation of the ubiquitin E3 ligase TRIM25.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF
    • Supplementary Materials

• Perspective

  • Inhibiting the Response to VEGF in Diabetes

    By Junji Moriya, Napoleone Ferrara

    Science Signaling07 Jan 2014 : pe1 Full AccessRestricted Access

    Hyperglycemia dampens endothelial cell responses to VEGF by triggering receptor activation and degradation in a ligand-independent manner.

    • Abstract
    • Full Text
    • PDF

• Podcast

  • Science Signaling Podcast: 7 January 2014

    By Michaela U. Gack, Annalisa M. VanHook

    Science Signaling07 Jan 2014 : pc1 Full AccessRestricted Access

    A deubiquitinase promotes interferon production to prolong the antiviral response.

    • Abstract
    • Full Text

• Editors' Choice

  • From Milk to Memory

    By Leslie K. Ferrarelli

    Science Signaling07 Jan 2014 : ec1 Full AccessRestricted Access

    Absence of an inflammatory cytokine in maternal milk enhances hippocampal development and cognitive function in offspring.

    • Abstract

  • Counteracting Cannabis

    By Peter R. Stern

    Science Signaling07 Jan 2014 : ec2 Full AccessRestricted Access

    The universal precursor of steroid hormones acts as a negative allosteric modulator of cannabinoid receptors.

    • Abstract

  • Time to Go on a Diet

    By Jason D. Berndt

    Science Signaling07 Jan 2014 : ec3 Full AccessRestricted Access

    A high-fat diet affects circadian rhythms.

    • Abstract

  • G Structures

    By Valda K. Vinson

    Science Signaling07 Jan 2014 : ec4 Full AccessRestricted Access

    The structure of a human serotonin receptor was solved using a free-electron laser to analyze microcrystals.

    • Abstract

  • Playing Hide and Seek

    By Paula A. Kiberstis

    Science Signaling07 Jan 2014 : ec5 Full AccessRestricted Access

    Tumor cells become resistant to targeted therapies by eliminating the gene encoding the drug target from extrachromosomal DNA.

    • Abstract

  • More from mTOR

    By Paula A. Kiberstis

    Science Signaling07 Jan 2014 : ec6 Full AccessRestricted Access

    A drug in clinical use for other disorders delays progression of an untreatable mitochondrial disease in knockout mice.

    • Abstract

  • From Stimulating Regeneration to Provoking Fibrosis

    By Nancy R. Gough

    Science Signaling07 Jan 2014 : ec7 Full AccessRestricted Access

    A switch in receptor balance switches liver endothelial cells from promoting regeneration to stimulating fibrosis.

    • Abstract