Contents
Vol 7, Issue 308
Contents
Research Articles
- Antipsychotics Activate mTORC1-Dependent Translation to Enhance Neuronal Morphological Complexity
By stimulating the synthesis of a distinct set of proteins, antipsychotics increase neuronal complexity.
- PIP3 Induces the Recycling of Receptor Tyrosine Kinases
EGFR is recycled to the cell surface in response to the phosphoinositide PIP3.
- Switching of the Relative Dominance Between Feedback Mechanisms in Lipopolysaccharide-Induced NF-κB Signaling
Dueling feedback loops set the threshold for mounting an effective innate immune response to infection.
Podcast
- Science Signaling Podcast: 14 January 2014
Antipsychotics such as haloperidol affect neuronal morphology through the Akt-mTOR pathway.
Editors' Choice
- Guided by the Dying
A tissue that is destined for destruction directs the formation of its replacement by redeploying an embryonic patterning program.
- Noncoded Competition
The transcript of a protein-coding gene acts independently as a microRNA sponge to promote lung cancer.
- Deacetylase Activity Not Required
Catalytically inactive HDAC3 rescues mice with liver-specific deficiency in this enzyme from hepatosteatosis and altered lipid metabolism.
- Statins Inhibit YAP
Statins limit breast cancer cell migration by inhibiting the transcriptional coactivator YAP.
- Make Way for the Emerging Rootlet
Localized disruption of surrounding plant cell walls paves the way for lateral root development.
- Carbon Budding in the Ocean
The abundant marine cyanobacterium Prochlorococcus sheds membrane vesicles that may contribute to carbon budgets.
- Developing Neurons Make the Cut
During vertebrate neuronal development, the apical membrane is shed, allowing further differentiation.
- K-Ras Takes Sides
Oncogenic K-Ras promotes basal extrusion and survival of delaminated epithelial cells by decreasing the abundance of the signaling lipid S1P.
