Contents
Vol 7, Issue 309
Contents
Research Articles
- The Secreted Protein ANGPTL2 Promotes Metastasis of Osteosarcoma Cells Through Integrin α5β1, p38 MAPK, and Matrix Metalloproteinases
Preventing signaling by ANGPTL2, which is stimulated by the tumor microenvironment, could inhibit metastasis.
- Roquin-2 Promotes Ubiquitin-Mediated Degradation of ASK1 to Regulate Stress Responses
Roquin-2 promotes degradation of the kinase ASK1 to mediate an appropriate response to oxidative stress and infection.
- The Nutrient-Responsive Transcription Factor TFE3 Promotes Autophagy, Lysosomal Biogenesis, and Clearance of Cellular Debris
Enhancing TFE3 activity to promote expression of lysosome-associated genes may be beneficial in treating lysosomal storage disorders.
Podcast
- Science Signaling Podcast: 21 January 2014
Therapies that interfere with signaling by the secreted factor ANGPTL2 may decrease the likelihood of osteosarcoma metastasis.
Editors' Choice
- Metabolic Reprogramming with a Long Noncoding RNA
HIF-1α and lincRNA-p21 form a positive feedback loop that reprograms metabolism in response to hypoxia.
- Lymphoma Gets NIK’d
Some mantle cell lymphomas are addicted to alternative nuclear factor κB signaling, which is dependent on the kinase NIK.
- Drug with a (Re)Purpose
A drug with potent activity in multiple myeloma patients acts by inducing degradation of two specific transcription factors.
- ROR1 Generates Bad Blood
The receptor tyrosine kinase–like receptor ROR1 binds to the oncoprotein TCL1 to promote B cell leukemia.
- The Secret Life of a Vaccine
The success of the yellow fever vaccine is linked to the amino acid starvation pathway, which promotes adaptive immunity.
- ATP Receptor in Arabidopsis
An Arabidopsis lectin receptor kinase, DORN1, is the plant receptor for extracellular adenosine triphosphate.
- RIGging the Therapeutic Response
A protein that is involved in sensing viral RNA determines the response of hepatocellular carcinomas to interferon α.