21 January 2014
Vol 7, Issue 309

About The Cover

Cover image expansion

Online Cover This week features a Research Article that shows that enhancing TFE3 activity to promote expression of lysosome-associated genes may be beneficial in treating lysosomal storage disorders. The image shows myotubes of a model of a lysosomal storage disease overexpressing TFE3 and the appearance at the cell surface of a marker of lysosomes, indicating that the accumulated material was released from the cell. Nuclei are blue and the lysosomal marker protein is red. [Image: Nina Raben, Laboratory of Muscle Stem Cells and Gene Regulation, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health]