Contents

Contents

• Research Articles

  • The Secreted Protein ANGPTL2 Promotes Metastasis of Osteosarcoma Cells Through Integrin α₅β₁, p38 MAPK, and Matrix Metalloproteinases

    By Haruki Odagiri, Tsuyoshi Kadomatsu, Motoyoshi Endo, Tetsuro Masuda, Masaki Suimye Morioka, Shigetomo Fukuhara, Takeshi Miyamoto, Eisuke Kobayashi, Keishi Miyata, Jun Aoi, Haruki Horiguchi, Naotaka Nishimura, Kazutoyo Terada, Toshitake Yakushiji, Ichiro Manabe, Naoki Mochizuki, Hiroshi Mizuta, Yuichi Oike

    Science Signaling21 Jan 2014 : ra7 Full AccessRestricted Access

    Preventing signaling by ANGPTL2, which is stimulated by the tumor microenvironment, could inhibit metastasis.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF
    • Supplementary Materials

  • Roquin-2 Promotes Ubiquitin-Mediated Degradation of ASK1 to Regulate Stress Responses

    By Takeshi Maruyama, Toshihiro Araki, Yosuke Kawarazaki, Isao Naguro, Susanne Heynen, Pedro Aza-Blanc, Ze’ev Ronai, Atsushi Matsuzawa, Hidenori Ichijo

    Science Signaling21 Jan 2014 : ra8 Full AccessRestricted Access

    Roquin-2 promotes degradation of the kinase ASK1 to mediate an appropriate response to oxidative stress and infection.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF
    • Supplementary Materials

  • The Nutrient-Responsive Transcription Factor TFE3 Promotes Autophagy, Lysosomal Biogenesis, and Clearance of Cellular Debris

    By José A. Martina, Heba I. Diab, Li Lishu, Lim Jeong-A, Simona Patange, Nina Raben, Rosa Puertollano

    Science Signaling21 Jan 2014 : ra9 Full AccessRestricted Access

    Enhancing TFE3 activity to promote expression of lysosome-associated genes may be beneficial in treating lysosomal storage disorders.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF
    • Supplementary Materials

• Podcast

  • Science Signaling Podcast: 21 January 2014

    By Yuichi Oike, Annalisa M. VanHook

    Science Signaling21 Jan 2014 : pc3 Full AccessRestricted Access

    Therapies that interfere with signaling by the secreted factor ANGPTL2 may decrease the likelihood of osteosarcoma metastasis.

    • Abstract
    • Full Text

• Editors' Choice

  • Metabolic Reprogramming with a Long Noncoding RNA

    By Nancy R. Gough

    Science Signaling21 Jan 2014 : ec16 Full AccessRestricted Access

    HIF-1α and lincRNA-p21 form a positive feedback loop that reprograms metabolism in response to hypoxia.

    • Abstract

  • Lymphoma Gets NIK’d

    By John F. Foley

    Science Signaling21 Jan 2014 : ec17 Full AccessRestricted Access

    Some mantle cell lymphomas are addicted to alternative nuclear factor κB signaling, which is dependent on the kinase NIK.

    • Abstract

  • Drug with a (Re)Purpose

    By Paula A. Kiberstis

    Science Signaling21 Jan 2014 : ec18 Full AccessRestricted Access

    A drug with potent activity in multiple myeloma patients acts by inducing degradation of two specific transcription factors.

    • Abstract

  • ROR1 Generates Bad Blood

    By Jason D. Berndt

    Science Signaling21 Jan 2014 : ec19 Full AccessRestricted Access

    The receptor tyrosine kinase–like receptor ROR1 binds to the oncoprotein TCL1 to promote B cell leukemia.

    • Abstract

  • The Secret Life of a Vaccine

    By Helen Pickersgill

    Science Signaling21 Jan 2014 : ec20 Full AccessRestricted Access

    The success of the yellow fever vaccine is linked to the amino acid starvation pathway, which promotes adaptive immunity.

    • Abstract

  • ATP Receptor in Arabidopsis

    By Pamela J. Hines

    Science Signaling21 Jan 2014 : ec21 Full AccessRestricted Access

    An Arabidopsis lectin receptor kinase, DORN1, is the plant receptor for extracellular adenosine triphosphate.

    • Abstract

  • RIGging the Therapeutic Response

    By Leslie K. Ferrarelli

    Science Signaling21 Jan 2014 : ec22 Full AccessRestricted Access

    A protein that is involved in sensing viral RNA determines the response of hepatocellular carcinomas to interferon α.

    • Abstract