Contents
Vol 7, Issue 310
Contents
Research Articles
- ROMO1 Is an Essential Redox-Dependent Regulator of Mitochondrial Dynamics
ROMO1 links the oxidative state of the cell to changes in mitochondrial shape and function.
- STAT3 Induction of miR-146b Forms a Feedback Loop to Inhibit the NF-κB to IL-6 Signaling Axis and STAT3-Driven Cancer Phenotypes
An epigenetic modification prevents the production of a tumor-suppressing and anti-inflammatory microRNA in receptor-negative breast cancers.
Perspectives
- O ROM(e)O1, ROM(e)O1, Wherefore Art Thou ROM(e)O1?
ROMO1 translates alterations in redox state into changes in mitochondrial morphology.
- Biasing GPCR Signaling from Inside
Strategies that target the intracellular domain of G protein–coupled receptors may enable development of new intracellular biased signaling modulators.
Editors' Choice
- Blood Vessels Direct Liver Regeneration
A vascular growth factor exerts paracrine control of hepatocyte proliferation and autocrine control of angiogenesis during liver regeneration.
- Gender-Specific Differences in Hematopoeisis
In female mice, estrogen stimulates hematopoietic stem cell division.
- Bacterial Lipids Help Gut It Out
Microbes in the gut produce lipids that signal to the host to establish symbiosis.
- An Immune Response to Malnutrition
Vitamin A deficiency alters the balance of innate immune cells in the gut, promoting resistance to nematode infection.
- Sensing HIV
The intracellular sensor that triggers the death of human lymphoid CD4 T cells abortively infected with HIV is identified.
- A Peptide Finds Its Receptor
A signaling system important in the regulation of plant cell size during development is identified.
- The Sugar-Cancer Connection in 3D
A three-dimensional culture model shows that increased glycolysis can initiate and maintain malignant phenotypes.
- Life or Death Decisions
The abundance of a phosphatase that targets a death receptor determines whether autophagy protects cells against apoptosis.
