Research ArticleCancer
STAT3 Induction of miR-146b Forms a Feedback Loop to Inhibit the NF-κB to IL-6 Signaling Axis and STAT3-Driven Cancer Phenotypes
- Michael Xiang1,
- Nicolai J. Birkbak2,*,
- Vida Vafaizadeh3,
- Sarah R. Walker1,4,
- Jennifer E. Yeh1,
- Suhu Liu1,
- Yasmin Kroll1,
- Mark Boldin5,†,
- Konstantin Taganov5,‡,
- Bernd Groner3,
- Andrea L. Richardson2, and
- David A. Frank1,4,§
- 1Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
- 2Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02215, USA.
- 3Georg-Speyer-Haus, Institute for Biomedical Research, D-60956 Frankfurt, Germany.
- 4Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02215, USA.
- 5Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA.
- ↵§Corresponding author. E-mail: david_frank{at}dfci.harvard.edu
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↵* Present address: Department of Systems Biology, Technical University of Denmark, 2800 Lyngby, Denmark.
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↵† Present address: Department of Molecular and Cellular Biology, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA.
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↵‡ Present address: EMD Millipore, 28820 Single Oak Drive, Temecula, CA 92590, USA.
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Science Signaling 28 Jan 2014:
Vol. 7, Issue 310, pp. ra11
DOI: 10.1126/scisignal.2004497