04 February 2014
Vol 7, Issue 311
  • Contents

    • Research Articles

    • Podcast

    • Editors' Choice

      • Battle of the Sexes

        Merely perceiving the opposite sex can shorten an animal’s life span.

      • Big MACs

        Benthic marine larval development is triggered by a bacterially expressed structure of phage origin.

      • Cyclin C Moves Out of the Nucleus

        The transcriptional repressor cyclin C leaves the nucleus to promote mitochondrial fission.

      • Building a Heart with Cyclin

        Cyclin and cyclin-dependent kinase activity play independent roles in the stimulation of the transcription factor GATA4.

      • Coordinating the Clock

        Flies use a mechanosensory organ to sense a low-frequency vibration and reset the brain’s biological clock.

      • A Matter of Timing

        A regulatory circuit controlling plant flowering genes leads the way to reconstruction of a time-delay control system.

      • Activating mTOR with Ral Instead of Rheb

        Lack of a key regulatory complex in worms leads to the identification of a previously unknown regulatory mechanism for mTOR in mammalian cells.

About The Cover

Cover image expansion

Online Cover This week features a Research Article that describes how systems biology can lead to intervention strategies to reverse kidney damage. The image is a pseudocolored high-resolution scanning electron micrograph of rat kidney podocytes that form the glomerular filtration barrier. [Image: Evren U. Azeloglu, Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai]