Research ArticleSystems Biology

Interconnected Network Motifs Control Podocyte Morphology and Kidney Function

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Science Signaling  04 Feb 2014:
Vol. 7, Issue 311, pp. ra12
DOI: 10.1126/scisignal.2004621

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From Networks to Drug Therapy

Drug-induced or disease-associated loss of kidney function involves the dedifferentiation and loss of the filtration barrier provided by the foot processes of the podocytes. Azeloglu et al. performed proteomics, network analysis, and dynamical modeling that yielded a plan for in vivo drug intervention in a rodent model of nephropathy. Information about the dynamic activity of motifs in a regulatory network was effectively leveraged to identify potential therapies to reverse drug-induced kidney damage. This study shows that systems biology and network analysis hold promise for identifying therapeutic strategies in diseases resulting from complex changes in cellular function.

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