Interconnected Network Motifs Control Podocyte Morphology and Kidney Function

Evren U. Azeloglu; Simon V. Hardy; Narat John Eungdamrong; Yibang Chen; Gomathi Jayaraman; Peter Y. Chuang; Wei Fang; Huabao Xiong; Susana R. Neves; Mohit R. Jain; Hong Li; Avi Ma’ayan; Ronald E. Gordon; John Cijiang He; Ravi Iyengar

doi:10.1126/scisignal.2004621

Research ArticleSystems Biology

Interconnected Network Motifs Control Podocyte Morphology and Kidney Function

Evren U. Azeloglu¹,*,
Simon V. Hardy¹,*,†,
Narat John Eungdamrong¹,‡,
Yibang Chen¹,
Gomathi Jayaraman¹,
Peter Y. Chuang²,
Wei Fang¹,
Huabao Xiong³,
Susana R. Neves¹,⁴,
Mohit R. Jain⁵,
Hong Li⁵,
Avi Ma’ayan¹,
Ronald E. Gordon⁶,
John Cijiang He¹,²,§¶, and
Ravi Iyengar¹,⁴,§¶

¹Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA.
²Division of Nephrology, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA.
³Immunobiology Center, Mount Sinai School of Medicine, New York, NY 10029, USA.
⁴Systems Biology Center New York, Mount Sinai School of Medicine, New York, NY 10029, USA.
⁵Department of Biochemistry and Molecular Biology, Center for Advanced Proteomics Research, University of Medicine and Dentistry of New Jersey–New Jersey Medical School Cancer Center, Newark, NJ 07103, USA.
⁶Department of Pathology, Mount Sinai School of Medicine, New York, NY 10029, USA.

↵¶Corresponding author. E-mail: ravi.iyengar{at}mssm.edu (R.I.); cijiang.he{at}mssm.edu (J.C.H.)

↵* These authors contributed equally to this work (joint first authors).
↵† Present address: Université Laval, 2325 Rue de l’Université, Québec, Québec G1V 0A6, Canada.
↵‡ Present address: New York University Medical Center, New York, NY 10016, USA.
↵§ These authors contributed equally to this work (joint senior authors).

See allHide authors and affiliations

Science Signaling 04 Feb 2014:
Vol. 7, Issue 311, pp. ra12
DOI: 10.1126/scisignal.2004621

Evren U. Azeloglu

1Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Simon V. Hardy

1Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Narat John Eungdamrong

1Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Yibang Chen

1Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Gomathi Jayaraman

1Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Peter Y. Chuang

2Division of Nephrology, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Wei Fang

1Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Huabao Xiong

3Immunobiology Center, Mount Sinai School of Medicine, New York, NY 10029, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Susana R. Neves

1Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA.

4Systems Biology Center New York, Mount Sinai School of Medicine, New York, NY 10029, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Mohit R. Jain

5Department of Biochemistry and Molecular Biology, Center for Advanced Proteomics Research, University of Medicine and Dentistry of New Jersey–New Jersey Medical School Cancer Center, Newark, NJ 07103, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Hong Li

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Avi Ma’ayan

1Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Ronald E. Gordon

6Department of Pathology, Mount Sinai School of Medicine, New York, NY 10029, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

John Cijiang He

1Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA.

2Division of Nephrology, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
For correspondence: ravi.iyengar@mssm.edu cijiang.he@mssm.edu

Ravi Iyengar

1Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA.

4Systems Biology Center New York, Mount Sinai School of Medicine, New York, NY 10029, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
For correspondence: ravi.iyengar@mssm.edu cijiang.he@mssm.edu

Article
Figures & Data
Info & Metrics
eLetters
PDF

eLetters is an online forum for ongoing peer review. Submission of eLetters are open to all. Please read our Terms of Service before submitting your own eLetter.

Submit a Response to This Article

Compose eLetter

Title

Contents

More information about text formats

Plain text

Plain text
No HTML tags allowed.
Web page addresses and e-mail addresses turn into links automatically.
Lines and paragraphs break automatically.

Author Information

Contributors
First name and middle name First or given name, e.g. 'Peter'. Last Name Your last, or family, name, e.g. 'MacMoody'. Email Your email address, e.g. higgs-boson@gmail.com Role / Occupation Your role and/or occupation, e.g. 'Orthopedic Surgeon'. Affiliation Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.

Statement of Competing Interests

Competing interests?

Yes

Please describe the competing interests

CAPTCHA

This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Vertical Tabs

No eLetters have been published for this article.

View Full Text

Interconnected Network Motifs Control Podocyte Morphology and Kidney Function

Plain text

Vertical Tabs

Science Signaling

Article Tools