Contents
Vol 7, Issue 312
Contents
Research Articles
- The Bcl-2 Homolog Nrz Inhibits Binding of IP3 to Its Receptor to Control Calcium Signaling During Zebrafish Epiboly
Phosphorylation of a Bcl-2–like protein allows calcium signals needed for the early stages of development.
- β1 Integrin Inhibition Elicits a Prometastatic Switch Through the TGFβ–miR-200–ZEB Network in E-Cadherin–Positive Triple-Negative Breast Cancer
Although some breast cancer therapies reduce the primary tumor, they may trigger unwanted metastasis.
Perspective
- The IP3 Receptor as a Hub for Bcl-2 Family Proteins in Cell Death Control and Beyond
Bcl-2 family proteins regulate calcium signaling.
Podcast
- Science Signaling Podcast: 11 February 2014
Inhibiting signaling through β1 integrin reduces tumor growth but promotes metastasis in a type of breast cancer.
Editors' Choice
- The Message in the Medium
The etiquette of yeast cells that secrete signals that influence themselves and their neighbors is explored.
- A Notch Closer to Understanding Multiple Sclerosis
Inhibiting endothelin signaling decreases Notch activation and enables oligodendrocyte maturation in MS-like lesions.
- The Switch That Doesn't
Maternal administration of bumetanide before delivery reduces the autistic phenotype in rodent models of autism.
- Causing Chloride Changes
Imaging of a fluorescent chloride indicator reveals a role for impermeant anions in setting intraneuronal chloride levels.
- From Channel to Sensor
The mossy fiber to the CA3 synapse operates via loose calcium microdomains established by local calcium buffering.
- Separate to Intercalate
PCP signaling establishes septin-mediated compartmentalization of cortical actomyosin domains to drive convergent extension during vertebrate gastrulation.
- N-End Rules Again
Nitric oxide promotes the degradation of a subfamily of ERF transcription factors, thereby contributing to regulation of seed germination.
Erratum
- A Correction to the Perspective Titled: “Inhibiting the Response to VEGF in Diabetes” by J. Moriya and N. Ferrara
An error in the figure of the orientation of VEGFR2 in the Golgi is corrected.