Contents

Contents

• Research Articles

  • The Bcl-2 Homolog Nrz Inhibits Binding of IP₃ to Its Receptor to Control Calcium Signaling During Zebrafish Epiboly

    By Benjamin Bonneau, Adrien Nougarède, Julien Prudent, Nikolay Popgeorgiev, Nadine Peyriéras, Ruth Rimokh, Germain Gillet

    Science Signaling11 Feb 2014 : ra14 Full AccessRestricted Access

    Phosphorylation of a Bcl-2–like protein allows calcium signals needed for the early stages of development.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF

  • β₁ Integrin Inhibition Elicits a Prometastatic Switch Through the TGFβ–miR-200–ZEB Network in E-Cadherin–Positive Triple-Negative Breast Cancer

    By Hoa H. Truong, Jiangling Xiong, Veerander P. S. Ghotra, Ella Nirmala, Lizette Haazen, Sylvia E. Le Dévédec, Hayri E. Balcioğlu, Shuning He, B. Ewa Snaar-Jagalska, Erno Vreugdenhil, John H. N. Meerman, Bob van de Water, Erik H. J. Danen

    Science Signaling11 Feb 2014 : ra15 Full AccessRestricted Access

    Although some breast cancer therapies reduce the primary tumor, they may trigger unwanted metastasis.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF

• Perspective

  • The IP₃ Receptor as a Hub for Bcl-2 Family Proteins in Cell Death Control and Beyond

    By Jan B. Parys

    Science Signaling11 Feb 2014 : pe4 Full AccessRestricted Access

    Bcl-2 family proteins regulate calcium signaling.

    • Abstract
    • Full Text
    • PDF

• Podcast

  • Science Signaling Podcast: 11 February 2014

    By Erik H. J. Danen, Annalisa M. VanHook

    Science Signaling11 Feb 2014 : pc5 Full AccessRestricted Access

    Inhibiting signaling through β₁ integrin reduces tumor growth but promotes metastasis in a type of breast cancer.

    • Abstract
    • Full Text

• Editors' Choice

  • The Message in the Medium

    By L. Bryan Ray

    Science Signaling11 Feb 2014 : ec38 Full AccessRestricted Access

    The etiquette of yeast cells that secrete signals that influence themselves and their neighbors is explored.

    • Abstract

  • A Notch Closer to Understanding Multiple Sclerosis

    By Leslie K. Ferrarelli

    Science Signaling11 Feb 2014 : ec39 Full AccessRestricted Access

    Inhibiting endothelin signaling decreases Notch activation and enables oligodendrocyte maturation in MS-like lesions.

    • Abstract

  • The Switch That Doesn't

    By Pamela J. Hines

    Science Signaling11 Feb 2014 : ec40 Full AccessRestricted Access

    Maternal administration of bumetanide before delivery reduces the autistic phenotype in rodent models of autism.

    • Abstract

  • Causing Chloride Changes

    By Peter R. Stern

    Science Signaling11 Feb 2014 : ec41 Full AccessRestricted Access

    Imaging of a fluorescent chloride indicator reveals a role for impermeant anions in setting intraneuronal chloride levels.

    • Abstract

  • From Channel to Sensor

    By Peter R. Stern

    Science Signaling11 Feb 2014 : ec42 Full AccessRestricted Access

    The mossy fiber to the CA3 synapse operates via loose calcium microdomains established by local calcium buffering.

    • Abstract

  • Separate to Intercalate

    By Annalisa M. VanHook

    Science Signaling11 Feb 2014 : ec43 Full AccessRestricted Access

    PCP signaling establishes septin-mediated compartmentalization of cortical actomyosin domains to drive convergent extension during vertebrate gastrulation.

    • Abstract

  • N-End Rules Again

    By Nancy R. Gough

    Science Signaling11 Feb 2014 : ec44 Full AccessRestricted Access

    Nitric oxide promotes the degradation of a subfamily of ERF transcription factors, thereby contributing to regulation of seed germination.

    • Abstract

• Erratum

  • A Correction to the Perspective Titled: “Inhibiting the Response to VEGF in Diabetes” by J. Moriya and N. Ferrara

    Science Signaling11 Feb 2014 : er1 Full AccessRestricted Access

    An error in the figure of the orientation of VEGFR2 in the Golgi is corrected.

    • Full Text
    • PDF