18 February 2014
Vol 7, Issue 313
  • Contents

    • Research Articles

    • Perspective

      • Cracking the NF-κB Code

        Quantitative analysis of nuclear factor κB signaling reveals critical feedback mechanisms.

    • Podcast

    • Editors' Choice

      • Biased in the Absence of Sodium

        The crystal structure of the δ opioid receptor reveals a sodium ion that influences downstream coupling efficiency and ligand affinity.

      • Gastrulating Cells Toddle

        A secreted peptide promotes gastrulation movements in zebrafish.

      • Timing Isn't Everything

        The segmentation clock is not required for vertebrate somite formation but is required for temporal regulation of somitogenesis.

      • A New Target to Halt RAS

        GEF-H1 promotes positive feedback in oncogenic RAS-MAPK signaling by enabling the activation of KSR1.

      • Fine-Tuning Brain Gyrations

        Development of surface folds of the human brain is controlled in sections.

      • Keeping Alphaviruses Under Wraps

        Alphaviruses use secondary structural elements in their genomic RNA to avoid host detection.

      • RIGging the Proliferative Response

        Retinoic acid–inducible gene I restricts the proliferation of myeloid progenitor cells independently of its role in antiviral responses.

About The Cover

Cover image expansion

Online Cover This week features a Research Article that suggests that factors secreted by tumor cells inhibit the differentiation of dendritic cell progenitors, thus inhibiting the antitumor immune response. The image is an artist's depiction of the effect of tumor-derived factors (red haze) on immune cells in the tumor microenvironment. [Image: Val Altounian, AAAS]