Contents

Contents

• Research Article

  • KCNQ1, KCNE2, and Na⁺-Coupled Solute Transporters Form Reciprocally Regulating Complexes That Affect Neuronal Excitability

    By Geoffrey W. Abbott, Kwok-Keung Tai, Daniel L. Neverisky, Alex Hansler, Zhaoyang Hu, Torsten K. Roepke, Daniel J. Lerner, Qiuying Chen, Li Liu, Bojana Zupan, Miklos Toth, Robin Haynes, Xiaoping Huang, Didem Demirbas, Roberto Buccafusca, Steven S. Gross, Vikram A. Kanda, Gerard T. Berry

    Science Signaling04 Mar 2014 : ra22 Full AccessRestricted Access

    Complexes of solute transporters and potassium channels that reciprocally regulate each other may contribute to seizure susceptibility.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF
    • Supplementary Materials

• Research Resource

  • mMAPS: A Flow-Proteometric Technique to Analyze Protein-Protein Interactions in Individual Signaling Complexes

    By Chao-Kai Chou, Heng-Huan Lee, Pei-Hsiang Tsou, Chun-Te Chen, Jung-Mao Hsu, Hirohito Yamaguchi, Ying-Nai Wang, Hong-Jen Lee, Jennifer L. Hsu, Jin-Fong Lee, Jun Kameoka, Mien-Chie Hung

    Science Signaling04 Mar 2014 : rs1 Full AccessRestricted Access

    Flow proteometry, fluorescence-based sorting of proteins, reveals the composition of individual protein-containing complexes.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF
    • Supplementary Materials

• Perspective

  • A Year in Structural Signaling: mTOR—The PIKK of the Bunch?

    By Stephen J. Smerdon

    Science Signaling04 Mar 2014 : pe6 Full AccessRestricted Access

    Protein crystallography reveals the secrets to regulation of the kinase mTOR.

    • Abstract
    • Full Text
    • PDF

• Podcast

  • Science Signaling Podcast: 4 March 2014

    By Geoffrey W. Abbott, Annalisa M. VanHook

    Science Signaling04 Mar 2014 : pc7 Full AccessRestricted Access

    A small-molecule transporter and a potassium channel cooperate to modulate the composition of cerebrospinal fluid and seizure susceptibility.

    • Abstract
    • Full Text

• Editors' Choice

  • Brain Tumor by NF-κB Fusion

    By Nancy R. Gough

    Science Signaling04 Mar 2014 : ec61 Full AccessRestricted Access

    A chromosomal fusion involving a gene encoding a subunit of the NF-κB transcription factor drives oncogenesis of a subset of brain tumors.

    • Abstract

  • Oncogenic Suspect Exposed

    By Paula A. Kiberstis

    Science Signaling04 Mar 2014 : ec62 Full AccessRestricted Access

    A rare form of liver cancer affecting young adults expresses a chimeric kinase that may contribute to pathogenesis.

    • Abstract

  • ERK Poises RNA Pol II

    By Jason D. Berndt

    Science Signaling04 Mar 2014 : ec63 Full AccessRestricted Access

    ERK2 phosphorylates RNA polymerase II in embryonic stem cells.

    • Abstract

  • A Different Route

    By Pamela J. Hines

    Science Signaling04 Mar 2014 : ec64 Full AccessRestricted Access

    An alternate signaling route for the plant hormone auxin goes directly inside from the cell surface.

    • Abstract

  • A New Target in Diabetes

    By Leslie K. Ferrarelli

    Science Signaling04 Mar 2014 : ec65 Full AccessRestricted Access

    Preventing the translocation of p53 to the cytosol in β cells promotes insulin secretion in animal models of type 1 and type 2 diabetes.

    • Abstract

  • Stressed Out About Crohn’s Disease

    By Annalisa M. VanHook

    Science Signaling04 Mar 2014 : ec66 Full AccessRestricted Access

    A single-nucleotide polymorphism impairs autophagy and stimulates inflammation by increasing turnover of the Crohn's disease–associated autophagy protein ATG16L1.

    • Abstract

  • Allergen Affinity

    By L. Bryan Ray

    Science Signaling04 Mar 2014 : ec67 Full AccessRestricted Access

    One receptor uses different signals to achieve different outcomes.

    • Abstract

• Erratum

  • A Correction to the Research Article Titled: “The Adaptor Protein p66Shc Inhibits mTOR-Dependent Anabolic Metabolism” by M. A. Soliman, A. M. Abdel Rahman, D. A. Lamming, K. Birsoy, J. Pawling, M. E. Frigolet, H. Lu, I. G. Fantus, A. Pasculescu,Y. Zheng, D. M. Sabatini, J. W. Dennis, T. Pawson

    Science Signaling04 Mar 2014 : er2 Full AccessRestricted Access

    A correction to an author’s middle initial is made.

    • Full Text
    • PDF