Contents
Vol 7, Issue 315
Contents
Research Article
- KCNQ1, KCNE2, and Na+-Coupled Solute Transporters Form Reciprocally Regulating Complexes That Affect Neuronal Excitability
Complexes of solute transporters and potassium channels that reciprocally regulate each other may contribute to seizure susceptibility.
Research Resource
- mMAPS: A Flow-Proteometric Technique to Analyze Protein-Protein Interactions in Individual Signaling Complexes
Flow proteometry, fluorescence-based sorting of proteins, reveals the composition of individual protein-containing complexes.
Perspective
- A Year in Structural Signaling: mTOR—The PIKK of the Bunch?
Protein crystallography reveals the secrets to regulation of the kinase mTOR.
Podcast
- Science Signaling Podcast: 4 March 2014
A small-molecule transporter and a potassium channel cooperate to modulate the composition of cerebrospinal fluid and seizure susceptibility.
Editors' Choice
- Brain Tumor by NF-κB Fusion
A chromosomal fusion involving a gene encoding a subunit of the NF-κB transcription factor drives oncogenesis of a subset of brain tumors.
- Oncogenic Suspect Exposed
A rare form of liver cancer affecting young adults expresses a chimeric kinase that may contribute to pathogenesis.
- A Different Route
An alternate signaling route for the plant hormone auxin goes directly inside from the cell surface.
- A New Target in Diabetes
Preventing the translocation of p53 to the cytosol in β cells promotes insulin secretion in animal models of type 1 and type 2 diabetes.
- Stressed Out About Crohn’s Disease
A single-nucleotide polymorphism impairs autophagy and stimulates inflammation by increasing turnover of the Crohn's disease–associated autophagy protein ATG16L1.
Erratum
- A Correction to the Research Article Titled: “The Adaptor Protein p66Shc Inhibits mTOR-Dependent Anabolic Metabolism” by M. A. Soliman, A. M. Abdel Rahman, D. A. Lamming, K. Birsoy, J. Pawling, M. E. Frigolet, H. Lu, I. G. Fantus, A. Pasculescu,Y. Zheng, D. M. Sabatini, J. W. Dennis, T. Pawson
A correction to an author’s middle initial is made.
