PerspectiveStructural Biology

A Year in Structural Signaling: mTOR—The PIKK of the Bunch?

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Science Signaling  04 Mar 2014:
Vol. 7, Issue 315, pp. pe6
DOI: 10.1126/scisignal.2005174


  • Fig. 1 Kinase crystal structures reveal functionally important and medically relevant secrets.

    (A) The first crystal structure of protein kinase PKA shows the classical N-lobe (blue) and C-lobe (yellow) configuration with the nucleotide binding site and catalytic residues located in a cleft between the lobes. (B) Domains present in all PIKK family members of atypical serine-threonine kinases. (C) The TORC1 and TORC2 complexes, their regulatory inputs, and functional outputs are shown. (D) X-ray structure of the mTOR-mLST8 core assembly in complex with a nonhydrolyzable ATP analog (shown as spheres). N-lobe and C-lobe denote the N-terminal and C-terminal regions, respectively, of the bilobed kinase domain.


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