Contents

Contents

• Editorial Guide

  • Focus Issue: Refining the War on Cancer

    By Leslie K. Ferrarelli

    Science Signaling25 Mar 2014 : eg2 Full AccessRestricted Access

    Cancer therapies must not only prevent tumor growth, but also prevent the development of drug resistance and metastases.

    • Abstract
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• Research Articles

  • Antagonism of EGFR and HER3 Enhances the Response to Inhibitors of the PI3K-Akt Pathway in Triple-Negative Breast Cancer

    By Jessica J. Tao, Pau Castel, Nina Radosevic-Robin, Moshe Elkabets, Neil Auricchio, Nicola Aceto, Gregory Weitsman, Paul Barber, Borivoj Vojnovic, Haley Ellis, Natasha Morse, Nerissa Therese Viola-Villegas, Ana Bosch, Dejan Juric, Saswati Hazra, Sharat Singh, Phillip Kim, Anna Bergamaschi, Shyamala Maheswaran, Tony Ng, Frédérique Penault-Llorca, Jason S. Lewis, Lisa A. Carey, Charles M. Perou, José Baselga, Maurizio Scaltriti

    Science Signaling25 Mar 2014 : ra29 Full AccessRestricted Access

    Predictions regarding drug resistance mechanisms and treatment strategies in triple-negative breast cancer are confirmed in tumors from patients.

    • Editor's Summary
    • Abstract
    • Full Text
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  • BRAF Inhibitors Induce Metastasis in RAS Mutant or Inhibitor-Resistant Melanoma Cells by Reactivating MEK and ERK Signaling

    By Berta Sanchez-Laorden, Amaya Viros, Maria Romina Girotti, Malin Pedersen, Grazia Saturno, Alfonso Zambon, Dan Niculescu-Duvaz, Samra Turajlic, Andrew Hayes, Martin Gore, James Larkin, Paul Lorigan, Martin Cook, Caroline Springer, Richard Marais

    Science Signaling25 Mar 2014 : ra30 Full AccessRestricted Access

    When therapy leads to cancer metastasis, knowing where else to target in the pathway may be the key to successful treatment.

    • Editor's Summary
    • Abstract
    • Full Text
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• Perspectives

  • MicroRNA Circuits Regulate the Cancer-Inflammation Link

    By Dimitrios Iliopoulos

    Science Signaling25 Mar 2014 : pe8 Full AccessRestricted Access

    Increased inflammatory signaling in breast cancer is explained by the loss of a negative feedback loop.

    • Abstract
    • Full Text
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  • Flipping the Switch: Integrin Switching Provides Metastatic Competence

    By Aasakiran Madamanchi, Andries Zijlstra, Mary M. Zutter

    Science Signaling25 Mar 2014 : pe9 Full AccessRestricted Access

    Tumor growth and metastasis is delicately regulated by distinct β integrins.

    • Abstract
    • Full Text
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• Podcast

  • Science Signaling Podcast: 25 March 2014

    By Maurizio Scaltriti, Annalisa M. VanHook

    Science Signaling25 Mar 2014 : pc9 Full AccessRestricted Access

    A combination therapy that targets the PI3K-Akt pathway and signaling through the growth factor receptors EGFR and HER3 may be effective against triple-negative breast cancer.

    • Abstract
    • Full Text

• Editors' Choice

  • Life and Cell Death

    By L. Bryan Ray

    Science Signaling25 Mar 2014 : ec77 Full AccessRestricted Access

    A particular protein kinase functions at a critical control point that determines whether—and how—cells die.

    • Abstract

  • Cacophonous Clock

    By Jason D. Berndt

    Science Signaling25 Mar 2014 : ec78 Full AccessRestricted Access

    Circadian rhythms in the inner ear protect against hearing damage.

    • Abstract

  • Suppressed by B Cells

    By Nancy R. Gough

    Science Signaling25 Mar 2014 : ec79 Full AccessRestricted Access

    A subset of B cells secretes the immunosuppressive cytokine IL-35, which has implications for autoimmune disease and infection.

    • Abstract

  • Context-Dependent Antimicrobial Responses

    By John F. Foley

    Science Signaling25 Mar 2014 : ec80 Full AccessRestricted Access

    Simultaneous signaling through interferon-γ receptor and immunoglobulin G receptor pathways generates antimicrobial responses in macrophages.

    • Abstract

  • Resolving a Painful Controversy

    By Nancy R. Gough

    Science Signaling25 Mar 2014 : ec81 Full AccessRestricted Access

    Peripheral δ opioid receptors could function in both touch and pain perception in a previously unknown class of sensory neurons.

    • Abstract

  • Promoting Insulin Secretion

    By Wei Wong

    Science Signaling25 Mar 2014 : ec82 Full AccessRestricted Access

    An AMPK family kinase could be targeted to increase insulin secretion in prediabetic states.

    • Abstract