Contents
Vol 7, Issue 318
Contents
Editorial Guide
- Focus Issue: Refining the War on Cancer
Cancer therapies must not only prevent tumor growth, but also prevent the development of drug resistance and metastases.
Research Articles
- Antagonism of EGFR and HER3 Enhances the Response to Inhibitors of the PI3K-Akt Pathway in Triple-Negative Breast Cancer
Predictions regarding drug resistance mechanisms and treatment strategies in triple-negative breast cancer are confirmed in tumors from patients.
- BRAF Inhibitors Induce Metastasis in RAS Mutant or Inhibitor-Resistant Melanoma Cells by Reactivating MEK and ERK Signaling
When therapy leads to cancer metastasis, knowing where else to target in the pathway may be the key to successful treatment.
Perspectives
- MicroRNA Circuits Regulate the Cancer-Inflammation Link
Increased inflammatory signaling in breast cancer is explained by the loss of a negative feedback loop.
- Flipping the Switch: Integrin Switching Provides Metastatic Competence
Tumor growth and metastasis is delicately regulated by distinct β integrins.
Podcast
- Science Signaling Podcast: 25 March 2014
A combination therapy that targets the PI3K-Akt pathway and signaling through the growth factor receptors EGFR and HER3 may be effective against triple-negative breast cancer.
Editors' Choice
- Life and Cell Death
A particular protein kinase functions at a critical control point that determines whether—and how—cells die.
- Suppressed by B Cells
A subset of B cells secretes the immunosuppressive cytokine IL-35, which has implications for autoimmune disease and infection.
- Context-Dependent Antimicrobial Responses
Simultaneous signaling through interferon-γ receptor and immunoglobulin G receptor pathways generates antimicrobial responses in macrophages.
- Resolving a Painful Controversy
Peripheral δ opioid receptors could function in both touch and pain perception in a previously unknown class of sensory neurons.
- Promoting Insulin Secretion
An AMPK family kinase could be targeted to increase insulin secretion in prediabetic states.