22 April 2014
Vol 7, Issue 322
  • Contents

    • Research Articles

    • Podcast

      • Science Signaling Podcast: 22 April 2014

        Lamin-A links the nuclear skeleton with the cytoskeleton to modulate signaling through immunological synapses.

    • Editors' Choice

      • Sabotaging Immunosurveillance

        Some cancer therapies may be a double-edged sword, blocking pathways that mediate tumor growth and those mediating immune recognition.

      • miRly Interfering with Junctions

        An exosome-delivered and cancer cell–derived microRNA increases vascular permeability and promotes metastasis.

      • Inhibited from Across the Way

        Cis presentation of neuropilin 1 with the vascular growth factor receptor promotes angiogenesis, whereas trans presentation inhibits angiogenesis.

      • Universal Immune Function

        A heterodimer stands at the ready; a homodimer responds with action.

      • Defended by Lipids

        Lipid signals mediate the response to mitochondrial stress.

About The Cover

Cover image expansion

Online Cover This week features a Research Article that suggests that the nuclear skeleton, in particular nuclear lamin-A, and the cytoplasmic skeleton, in particular F-actin, cooperate in T cell activation. The image shows an artist's rendition of how nuclear lamin-A proteins in the T cell (blue) might stabilize the F-actin network at the contact region with an antigen-presenting cell (orange). [Image: Val Altounian, Science Signaling]