Contents
Vol 7, Issue 323
Contents
Research Articles
- Screening of Odor-Receptor Pairs in Caenorhabditis elegans Reveals Different Receptors for High and Low Odor Concentrations
Distinct receptors and neuronal circuits enable worms to move toward low and away from high concentrations of the same chemical.
- The DEAH-Box RNA Helicase DHX15 Activates NF-κB and MAPK Signaling Downstream of MAVS During Antiviral Responses
Different RNA helicases mediate distinct responses in cells infected with RNA viruses.
Research Resource
- Proteome-Wide Identification of SUMO2 Modification Sites
A novel method for the enrichment of SUMO2-modified peptides reveals more than 1000 sites of modification in human cells.
Perspective
- Mucus, It Is Not Just a Static Barrier
NLRP6 activates autophagy in intestinal goblet cells to promote mucus secretion and prevent microbial infection.
Editors' Choice
- Ironing Out Macrophages
Although hypoferremia inhibits the growth of extracellular bacteria, it stimulates the growth of the intracellular pathogen Salmonella.
- Trapped in Fat
Netrin and its receptor Unc5b contribute to obesity-induced inflammation by promoting the retention of macrophages in adipose tissue.
- Modifying Mitochondrial Metabolism
Glutarylation of lysine residues occurs in proteins involved in cellular metabolism and is regulated by diet.
- Stiff Path to Malignancy
Stiffening in the extracellular matrix inhibits the abundance of tumor suppressor PTEN in breast epithelial cells.
- Cycling Akt Activity
Phosphorylation at C-terminal sites contributes to the increases in Akt activity associated with the cell cycle, growth factor signaling, and DNA damage.
- No Light Control
In plants, light-dependent regulation of nuclear alternative splicing involves a signal generated within the chloroplast.
- Optogenetic Inhibition
Engineered light-sensitive ion channels allow rapid and reversible neuronal inhibition.
Erratum
