Research ArticleImmunology

Protein Tyrosine Phosphatase 1B Is a Regulator of the Interleukin-10–Induced Transcriptional Program in Macrophages

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Science Signaling  06 May 2014:
Vol. 7, Issue 324, pp. ra43
DOI: 10.1126/scisignal.2005020

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Tailoring Cytokine Responses

Although the proinflammatory cytokine interleukin-6 (IL-6) and the anti-inflammatory cytokine IL-10 activate the same transcription factor [signal transducer and activator of transcription 3 (STAT3)], which requires tyrosine phosphorylation, they stimulate the expression of distinct genes. Pike et al. found that mouse macrophages deficient in the protein tyrosine phosphatase 1B (PTP1B) exhibited enhanced activation of STAT3 in response to IL-10, but not IL-6, as well as increased expression of genes required for anti-inflammatory responses. Furthermore, unchecked IL-10 signaling led to the expression of a distinct set of inflammation-associated genes, suggesting that phosphatases may regulate both the identity and extent of expression of cytokine target genes.

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