Contents
Vol 7, Issue 325
Contents
Research Articles
- A Nanoparticle-Based Combination Chemotherapy Delivery System for Enhanced Tumor Killing by Dynamic Rewiring of Signaling Pathways
Nanoparticles containing two drugs released at different times effectively kill tumor cells.
- T Cell Receptor Signals to NF-κB Are Transmitted by a Cytosolic p62-Bcl10-Malt1-IKK Signalosome
Assembly of a multiprotein complex containing the adaptor protein p62 promotes NF-κB activation in T cells.
Research Resource
- Parallel Profiling of the Transcriptome, Cistrome, and Epigenome in the Cellular Response to Ionizing Radiation
Deep sequencing identifies the epigenetic and transcriptional dynamics of the cellular response to ionizing radiation.
Perspective
- Combinatorial Nanotherapeutics: Rewiring, Then Killing, Cancer Cells
Staggered release of two drugs from a liposomal nanoparticle rewires cellular pathways and promotes enhanced antitumor efficacy.
Editors' Choice
- Signals of a Successful Bariatric Surgery
Vertical sleeve gastrectomy, a surgery to reduce stomach size, requires signaling by the farsenoid-X receptor to effectively treat obesity.
- Bettering Your Elders
Factors present in young animals rejuvenate muscular and neural function in aged mice.
- WNTs Hitch a Ride
Migratory neural crest cells deliver WNTs from the dorsal neural tube to developing muscle myotubes to promote polarization.
- One Hormone, Two Phases
Inflorescence architecture is shaped by a biphasic signaling network involving the plant hormone gibberellin.
- One Swell Ion Channel
Components of an elusive swelling-activated anion channel are identified and form a structurally new class of channel.
- T Cells for Epithelial Tumors
T cells specific for a mutation expressed by tumor cells show antitumor activity in a patient with an epithelial cancer.
- Casting a NET in Gout
Aggregated neutrophil extracellular traps resolve gout-associated inflammation by degrading proinflammatory mediators.
