Contents

Contents

• Research Articles

  • A Nanoparticle-Based Combination Chemotherapy Delivery System for Enhanced Tumor Killing by Dynamic Rewiring of Signaling Pathways

    By Stephen W. Morton, Michael J. Lee, Zhou J. Deng, Erik C. Dreaden, Elise Siouve, Kevin E. Shopsowitz, Nisarg J. Shah, Michael B. Yaffe, Paula T. Hammond

    Science Signaling13 May 2014 : ra44 Full AccessRestricted Access

    Nanoparticles containing two drugs released at different times effectively kill tumor cells.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF
    • Supplementary Materials

  • T Cell Receptor Signals to NF-κB Are Transmitted by a Cytosolic p62-Bcl10-Malt1-IKK Signalosome

    By Suman Paul, Maria K. Traver, Anuj K. Kashyap, Michael A. Washington, Joseph R. Latoche, Brian C. Schaefer

    Science Signaling13 May 2014 : ra45 Full AccessRestricted Access

    Assembly of a multiprotein complex containing the adaptor protein p62 promotes NF-κB activation in T cells.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF
    • Supplementary Materials

• Research Resource

  • Parallel Profiling of the Transcriptome, Cistrome, and Epigenome in the Cellular Response to Ionizing Radiation

    By Sharon Rashi-Elkeles, Hans-Jörg Warnatz, Ran Elkon, Ana Kupershtein, Yuliya Chobod, Arnon Paz, Vyacheslav Amstislavskiy, Marc Sultan, Hershel Safer, Wilfried Nietfeld, Hans Lehrach, Ron Shamir, Marie-Laure Yaspo, Yosef Shiloh

    Science Signaling13 May 2014 : rs3 Full AccessRestricted Access

    Deep sequencing identifies the epigenetic and transcriptional dynamics of the cellular response to ionizing radiation.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF
    • Supplementary Materials

• Perspective

  • Combinatorial Nanotherapeutics: Rewiring, Then Killing, Cancer Cells

    By Ronnie H. Fang, Liangfang Zhang

    Science Signaling13 May 2014 : pe13 Full AccessRestricted Access

    Staggered release of two drugs from a liposomal nanoparticle rewires cellular pathways and promotes enhanced antitumor efficacy.

    • Abstract
    • Full Text
    • PDF

• Editors' Choice

  • Signals of a Successful Bariatric Surgery

    By Nancy R. Gough

    Science Signaling13 May 2014 : ec124 Full AccessRestricted Access

    Vertical sleeve gastrectomy, a surgery to reduce stomach size, requires signaling by the farsenoid-X receptor to effectively treat obesity.

    • Abstract

  • Bettering Your Elders

    By Annalisa M. VanHook

    Science Signaling13 May 2014 : ec125 Full AccessRestricted Access

    Factors present in young animals rejuvenate muscular and neural function in aged mice.

    • Abstract

  • WNTs Hitch a Ride

    By Jason D. Berndt

    Science Signaling13 May 2014 : ec126 Full AccessRestricted Access

    Migratory neural crest cells deliver WNTs from the dorsal neural tube to developing muscle myotubes to promote polarization.

    • Abstract

  • One Hormone, Two Phases

    By Pamela J. Hines

    Science Signaling13 May 2014 : ec127 Full AccessRestricted Access

    Inflorescence architecture is shaped by a biphasic signaling network involving the plant hormone gibberellin.

    • Abstract

  • One Swell Ion Channel

    By Melissa McCartney

    Science Signaling13 May 2014 : ec128 Full AccessRestricted Access

    Components of an elusive swelling-activated anion channel are identified and form a structurally new class of channel.

    • Abstract

  • T Cells for Epithelial Tumors

    By Kristen L. Mueller

    Science Signaling13 May 2014 : ec129 Full AccessRestricted Access

    T cells specific for a mutation expressed by tumor cells show antitumor activity in a patient with an epithelial cancer.

    • Abstract

  • Casting a NET in Gout

    By Nancy R. Gough

    Science Signaling13 May 2014 : ec130 Full AccessRestricted Access

    Aggregated neutrophil extracellular traps resolve gout-associated inflammation by degrading proinflammatory mediators.

    • Abstract