Contents
Vol 7, Issue 326
Contents
Research Articles
- Reconstituted Human TPC1 Is a Proton-Permeable Ion Channel and Is Activated by NAADP or Ca2+
Stimuli that increase calcium or NAADP may promote proton release from the endosomes and lysosomes by activating TPC1.
- Targeting Poly(ADP-Ribose) Polymerase and the c-Myb–Regulated DNA Damage Response Pathway in Castration-Resistant Prostate Cancer
The DNA damage response is an appealing target for androgen inhibitor–resistant prostate cancer.
- Nongenomic Thyroid Hormone Signaling Occurs Through a Plasma Membrane–Localized Receptor
Signaling from a plasma membrane–associated receptor contributes to the effects of thyroid hormones on bones.
Podcast
- Science Signaling Podcast: 20 May 2014
An alternative form of a thyroid hormone receptor mediates nongenomic signaling at the plasma membrane.
Editors' Choice
- Dual Action Pain Modulator
TNF-α and its receptor TNFR1 provide an inhibiting input for peptidergic pain neurons and an enhancing input to nonpeptidergic pain neurons.
- Nerves Have the Nerve to Ask for It
Peripheral nerves release factors that trigger invasion by cancer cells.
- Crowding Impairs Sperm Motility
A TGF-β ligand acts as a neuroendocrine signal that promotes sperm motility under favorable reproductive conditions.
- The Hormone’s Message
A molecular mechanism for transmembrane signaling by the growth hormone receptor is elucidated.
- Antigenic Metabolites
Glycolytic metabolites react with bacterially produced riboflavin precursors to form antigens recognized by a T cell subtype.
- Degrees of Separation
A membrane and signaling protein interaction network for gene discovery and hypothesis generation is identified in Arabidopsis.
- Defective Astrocytes in Huntington’s
Deficiency in a potassium channel in astrocytes causes excitotoxic neuronal symptoms in mouse models of Huntington’s disease.
