Contents
Vol 7, Issue 328
Contents
Research Articles
- Store-Operated Calcium Entry Promotes the Degradation of the Transcription Factor Sp4 in Resting Neurons
Resting neurons use a specific calcium influx pathway to actively control transcription factor function.
- MLK3 Is Part of a Feedback Mechanism That Regulates Different Cellular Responses to Reactive Oxygen Species
Computational analysis of signaling networks reveals how cells can choose between proliferation and death in response to oxidative stress.
- The ABA Receptor PYL8 Promotes Lateral Root Growth by Enhancing MYB77-Dependent Transcription of Auxin-Responsive Genes
Plants use an alternative abscisic acid signaling pathway to promote lateral root growth.
Podcast
- Science Signaling Podcast: 3 June 2014
A pressure-sensitive signaling pathway maintains constant blood flow to the brain.
Editors' Choice
- Less Pain (Receptors) Means a Longer Life
TRPV1, a receptor that responds to painful stimuli, may also alter glucose metabolism to reduce life span.
- Integrins Initiating Cancer
An integrin mediates the resistance of tumor-initiating cells to tyrosine kinase inhibitors in a ligand-independent manner.
- Treating Chronic Pain
Inhibiting a kinase that generates the lipid PIP2 in sensory neurons reduces susceptibility to chronic pain in mice.
- Pinpointing the Pressure Responder
Optogenetics and knockout mice demonstrate that Merkel cells, a specialized epidermal cell, actively contribute to touch perception.
- Intact NMDA Receptor Structure Revealed
Specific interactions between key neuronal receptor subunits and domains are critical for functional regulation.
- Making and Breaking Neuronal Synapses
Elimination of redundant synapses and formation of functional circuits in developing brain involves axon guidance molecules.
- High-Definition View of the Synapse
A model of the “average” synapse shows ~300,000 proteins and all organelles in the correct copy numbers, sizes, and positions.
- The Methyltransferase Shuffle
Two methyltransferases translocate from the plasma membrane to the nucleus to influence fungal developmental programs.
