Research ArticleCell Biology

Interplay Between the Oxidoreductase PDIA6 and microRNA-322 Controls the Response to Disrupted Endoplasmic Reticulum Calcium Homeostasis

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Science Signaling  10 Jun 2014:
Vol. 7, Issue 329, pp. ra54
DOI: 10.1126/scisignal.2004983

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Responding the Right Way to Cellular Stress

Some proteins must be folded correctly in the endoplasmic reticulum (ER) to function properly. Various stress conditions can cause the buildup of unfolded proteins in the ER, which can cause cell death. There are multiple ways in which cells can respond to deal with the buildup of unfolded proteins. Groenendyk et al. investigated how cells deal with the stress of depletion of calcium ions from the ER and identified a pathway involving a microRNA and an oxidoreductase in the ER. They found that depletion of calcium from the ER resulted in the decreased abundance of a microRNA, which enabled a target mRNA and the oxidoreductase it encoded to accumulate. The oxidoreductase then activated a specific stress response. The authors showed that this pathway could be present in mice and nematodes.