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vol. 7 no. 329 ra56
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History:
- Received October 30, 2013
- Accepted May 23, 2014
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Copyright © 2014, American Association for the Advancement of Science
Research ArticleCancer
Memo Is a Copper-Dependent Redox Protein with an Essential Role in Migration and Metastasis
- Gwen MacDonald1,*,
- Ivan Nalvarte1,*,†,
- Tatiana Smirnova1,
- Manuela Vecchi2,3,
- Nicola Aceto1,4,‡,
- Arno Doelemeyer5,
- Anna Frei1,4,
- Susanne Lienhard1,
- Jeffrey Wyckoff1,§,
- Daniel Hess1,
- Jan Seebacher1,
- Jeremy J. Keusch1,
- Heinz Gut1,
- Daniele Salaun6,
- Giovanni Mazzarol7,
- Davide Disalvatore8,
- Mohamed Bentires-Alj1,
- Pier Paolo Di Fiore2,3,9,
- Ali Badache6, and
- Nancy E. Hynes1,4,||
- 1Friedrich Miescher Institute for Biomedical Research, Basel 4058, Switzerland.
- 2IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan 20139, Italy.
- 3Molecular Medicine Program, Department of Experimental Oncology, European Institute of Oncology, Milan 20141, Italy.
- 4University of Basel, Basel 4002, Switzerland.
- 5Novartis Institutes for BioMedical Research, Basel 4057, Switzerland.
- 6Centre de Recherche en Cancérologie de Marseille, Inserm (U1068), Institut Paoli-Calmettes, Aix-Marseille Université, Centre National de la Recherche Scientifique (UMR7258), Marseille 13009, France.
- 7Division of Pathology and Laboratory Medicine, European Institute of Oncology, Milan 20141, Italy.
- 8Division of Epidemiology and Biostatistics, European Institute of Oncology, Milan 20141, Italy.
- 9Dipartimento di Scienze della Salute, Università degli Studi di Milano, Milan 20122, Italy.
- ↵||Corresponding author. E-mail: nancy.hynes{at}fmi.ch
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↵* These authors contributed equally to this work.
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↵† Present address: Department of Biosciences and Nutrition, Karolinska Institute, 14183 Huddinge, Sweden.
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↵‡ Present address: Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA 02129, USA.
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↵§ Present address: Koch Institute for Integrated Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA 02138, USA.
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Science Signaling 10 Jun 2014:
Vol. 7, Issue 329, pp. ra56
DOI: 10.1126/scisignal.2004870
Vol. 7, Issue 329, pp. ra56
DOI: 10.1126/scisignal.2004870
Gwen MacDonald
1Friedrich Miescher Institute for Biomedical Research, Basel 4058, Switzerland.
Ivan Nalvarte
1Friedrich Miescher Institute for Biomedical Research, Basel 4058, Switzerland.
Tatiana Smirnova
1Friedrich Miescher Institute for Biomedical Research, Basel 4058, Switzerland.
Manuela Vecchi
2IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan 20139, Italy.
3Molecular Medicine Program, Department of Experimental Oncology, European Institute of Oncology, Milan 20141, Italy.
Nicola Aceto
1Friedrich Miescher Institute for Biomedical Research, Basel 4058, Switzerland.
4University of Basel, Basel 4002, Switzerland.
Arno Doelemeyer
5Novartis Institutes for BioMedical Research, Basel 4057, Switzerland.
Anna Frei
1Friedrich Miescher Institute for Biomedical Research, Basel 4058, Switzerland.
4University of Basel, Basel 4002, Switzerland.
Susanne Lienhard
1Friedrich Miescher Institute for Biomedical Research, Basel 4058, Switzerland.
Jeffrey Wyckoff
1Friedrich Miescher Institute for Biomedical Research, Basel 4058, Switzerland.
Daniel Hess
1Friedrich Miescher Institute for Biomedical Research, Basel 4058, Switzerland.
Jan Seebacher
1Friedrich Miescher Institute for Biomedical Research, Basel 4058, Switzerland.
Jeremy J. Keusch
1Friedrich Miescher Institute for Biomedical Research, Basel 4058, Switzerland.
Heinz Gut
1Friedrich Miescher Institute for Biomedical Research, Basel 4058, Switzerland.
Daniele Salaun
6Centre de Recherche en Cancérologie de Marseille, Inserm (U1068), Institut Paoli-Calmettes, Aix-Marseille Université, Centre National de la Recherche Scientifique (UMR7258), Marseille 13009, France.
Giovanni Mazzarol
7Division of Pathology and Laboratory Medicine, European Institute of Oncology, Milan 20141, Italy.
Davide Disalvatore
8Division of Epidemiology and Biostatistics, European Institute of Oncology, Milan 20141, Italy.
Mohamed Bentires-Alj
1Friedrich Miescher Institute for Biomedical Research, Basel 4058, Switzerland.
Pier Paolo Di Fiore
2IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan 20139, Italy.
3Molecular Medicine Program, Department of Experimental Oncology, European Institute of Oncology, Milan 20141, Italy.
9Dipartimento di Scienze della Salute, Università degli Studi di Milano, Milan 20122, Italy.
Ali Badache
6Centre de Recherche en Cancérologie de Marseille, Inserm (U1068), Institut Paoli-Calmettes, Aix-Marseille Université, Centre National de la Recherche Scientifique (UMR7258), Marseille 13009, France.
Nancy E. Hynes
1Friedrich Miescher Institute for Biomedical Research, Basel 4058, Switzerland.
4University of Basel, Basel 4002, Switzerland.
