Contents
Vol 7, Issue 330
Contents
Research Articles
- A FAK-Cas-Rac-Lamellipodin Signaling Module Transduces Extracellular Matrix Stiffness into Mechanosensitive Cell Cycling
A signaling pathway triggers cell proliferation in response to increased stiffness in the external environment.
- The Kinase LMTK3 Promotes Invasion in Breast Cancer Through GRB2-Mediated Induction of Integrin β1
Targeting the kinase LMTK3 may prevent integrin-dependent metastasis in breast cancer.
Podcast
- Science Signaling Podcast: 17 June 2014
Stiff substrates prompt cells to activate a signaling network that stiffens the cytoskeleton and promotes proliferation.
Editors' Choice
- MAPK Methylation Potentiates RAS Signaling
Preventing a posttranslational modification in the MAPK pathway may block the growth of RAS-driven cancers.
- Dying on the Inside
Immune cells find a way to kill intracellular bacteria without killing the host cell.
- Meet Up at the Mitochondria
Two groups identify additional regulators of mitochondrial dynamics and degradation.
- The Crayfish That Was Afraid of the Light
Crayfish respond to stress with an apparent fear of the dark that can be abolished with an anxiolytic drug.
- Dissecting How Signaling Directs Axon Growth
The axon guidance protein netrin binds to two receptors with different architectures, providing a basis for diverse signaling outcomes.
- Improving Stroke Recovery by Timing Treatment
A rat model of stroke shows that the rebuilding of spinal circuits in response to training is time-sensitive.
