Contents

Contents

• Research Articles

  • Reliable Encoding of Stimulus Intensities Within Random Sequences of Intracellular Ca²⁺ Spikes

    By Kevin Thurley, Stephen C. Tovey, Gregor Moenke, Victoria L. Prince, Abha Meena, Andrew P. Thomas, Alexander Skupin, Colin W. Taylor, Martin Falcke

    Science Signaling24 Jun 2014 : ra59 Full AccessRestricted Access

    Mathematical analysis of Ca²⁺ signals in single cells reveals how cells can encode stimulus intensity in the frequency of Ca²⁺ spikes.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF

  • Triple-Color FRET Analysis Reveals Conformational Changes in the WIP-WASp Actin-Regulating Complex

    By Sophia Fried, Barak Reicher, Maor H. Pauker, Shani Eliyahu, Omri Matalon, Elad Noy, Jordan Chill, Mira Barda-Saad

    Science Signaling24 Jun 2014 : ra60 Full AccessRestricted Access

    Two interaction sites provide a mechanism to finely balance the activity and degradation of an actin-regulating protein complex.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF

  • LIMK-Dependent Actin Polymerization in Primary Sensory Neurons Promotes the Development of Inflammatory Heat Hyperalgesia in Rats

    By Yi Li, Fang Hu, Hai-Jing Chen, Yi-Juan Du, Zhi-Ying Xie, Ying Zhang, Jun Wang, Yun Wang

    Science Signaling24 Jun 2014 : ra61 Full AccessRestricted Access

    Inflammation-induced sensitivity to pain could be reduced by disrupting the actin cytoskeleton in primary sensory neurons.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF

• Editors' Choice

  • Mobilizing Hematopoietic Stem Cells

    By Annalisa M. VanHook

    Science Signaling24 Jun 2014 : ec168 Full AccessRestricted Access

    Pathogen-induced signaling through Toll-like and NOD-like receptors mobilizes hematopoietic stem cells to the spleen.

    • Abstract

  • Cytokine Rivalry

    By Angela C. Colmone

    Science Signaling24 Jun 2014 : ec169 Full AccessRestricted Access

    GM-CSF–producing T helper cells in humans follow a distinct regulation program as compared to T_H17 cells and are associated with multiple sclerosis.

    • Abstract

  • The IL-4 Brown Out

    By Jason D. Berndt

    Science Signaling24 Jun 2014 : ec170 Full AccessRestricted Access

    Immune cell activation promotes thermogenesis in white fat.

    • Abstract

  • Cell Fate Control—A Numbers Game

    By L. Bryan Ray

    Science Signaling24 Jun 2014 : ec171 Full AccessRestricted Access

    An analysis reveals how the very low terminal differentiation rates in adipocytes are maintained.

    • Abstract

  • A New Therapeutic Target in Uveal Melanoma

    By Leslie K. Ferrarelli

    Science Signaling24 Jun 2014 : ec172 Full AccessRestricted Access

    Inhibiting the transcriptional coactivator YAP in uveal melanoma with GNAQ or GNA11 mutations may suppress tumor growth in patients.

    • Abstract

  • Breaking Down the Invasion

    By Wei Wong

    Science Signaling24 Jun 2014 : ec173 Full AccessRestricted Access

    A pathway that triggers the breakdown of invadopodia in metastatic breast cancer cells is identified.

    • Abstract

  • Cancer at Single-Cell Resolution

    By Laura M. Zahn

    Science Signaling24 Jun 2014 : ec174 Full AccessRestricted Access

    Screening individual cancer cells within a brain tumor may help to guide treatment and predict prognosis.

    • Abstract

  • Yeast Metacaspase: Grim Reaper or Savior?

    By Stella M. Hurtley

    Science Signaling24 Jun 2014 : ec175 Full AccessRestricted Access

    An enzyme linked to cell death in animal cells protects yeast cells from misfolded protein aggregates.

    • Abstract

  • Preventing Myoblasts from Premature Differentiation

    By Nancy R. Gough

    Science Signaling24 Jun 2014 : ec176 Full AccessRestricted Access

    Endocannabinoids inhibit muscle differentiation.

    • Abstract

  • Breathing Freely

    By Orla M. Smith

    Science Signaling24 Jun 2014 : ec177 Full AccessRestricted Access

    Locking the integrin αvβ8 in a specific conformation inhibits TGF-β activation and ameliorates symptoms of airway disease in mice.

    • Abstract