Contents
Vol 7, Issue 331
Contents
Research Articles
- Reliable Encoding of Stimulus Intensities Within Random Sequences of Intracellular Ca2+ Spikes
Mathematical analysis of Ca2+ signals in single cells reveals how cells can encode stimulus intensity in the frequency of Ca2+ spikes.
- Triple-Color FRET Analysis Reveals Conformational Changes in the WIP-WASp Actin-Regulating Complex
Two interaction sites provide a mechanism to finely balance the activity and degradation of an actin-regulating protein complex.
- LIMK-Dependent Actin Polymerization in Primary Sensory Neurons Promotes the Development of Inflammatory Heat Hyperalgesia in Rats
Inflammation-induced sensitivity to pain could be reduced by disrupting the actin cytoskeleton in primary sensory neurons.
Editors' Choice
- Mobilizing Hematopoietic Stem Cells
Pathogen-induced signaling through Toll-like and NOD-like receptors mobilizes hematopoietic stem cells to the spleen.
- Cytokine Rivalry
GM-CSF–producing T helper cells in humans follow a distinct regulation program as compared to TH17 cells and are associated with multiple sclerosis.
- Cell Fate Control—A Numbers Game
An analysis reveals how the very low terminal differentiation rates in adipocytes are maintained.
- A New Therapeutic Target in Uveal Melanoma
Inhibiting the transcriptional coactivator YAP in uveal melanoma with GNAQ or GNA11 mutations may suppress tumor growth in patients.
- Breaking Down the Invasion
A pathway that triggers the breakdown of invadopodia in metastatic breast cancer cells is identified.
- Cancer at Single-Cell Resolution
Screening individual cancer cells within a brain tumor may help to guide treatment and predict prognosis.
- Yeast Metacaspase: Grim Reaper or Savior?
An enzyme linked to cell death in animal cells protects yeast cells from misfolded protein aggregates.
- Preventing Myoblasts from Premature Differentiation
Endocannabinoids inhibit muscle differentiation.
- Breathing Freely
Locking the integrin αvβ8 in a specific conformation inhibits TGF-β activation and ameliorates symptoms of airway disease in mice.