24 June 2014
Vol 7, Issue 331

About The Cover

Cover image expansion

Online Cover This week features a Research Article that combines mathematical theory and experiments with cultured cells to demonstrate how a variable element in the interspike interval between Ca2+ spikes can reliably encode changes in stimulus intensity. Similar to ability to recognize the same melody played on a large cello or a small violin, cells with different frequencies in the spikes decode the same fold change to respond appropriately to changes in the strength of stimulus. The image shows a cello and a violin with representative Ca2+ spike frequencies from cells in a population, illustrating the variablity in spike frequency the population. [Image: Thinkstock/Getty Images for the instruments]