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vol. 7 no. 331 ra59
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- Received March 3, 2014
- Accepted June 5, 2014
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Copyright © 2014, American Association for the Advancement of Science
Research ArticleCalcium signaling
Reliable Encoding of Stimulus Intensities Within Random Sequences of Intracellular Ca2+ Spikes
- Kevin Thurley1,2,3,
- Stephen C. Tovey2,
- Gregor Moenke1,
- Victoria L. Prince4,
- Abha Meena2,
- Andrew P. Thomas4,
- Alexander Skupin5,6,
- Colin W. Taylor2,*, and
- Martin Falcke1,7,*
- 1Mathematical Cell Physiology, Max Delbrück Center for Molecular Medicine, Robert Rössle Straße 10, Berlin 13125, Germany.
- 2Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK.
- 3Institute for Theoretical Biology, Charité-Universitätsmedizin Berlin, Invalidenstraße 43, Berlin 10115, Germany.
- 4Department of Pharmacology and Physiology, New Jersey Medical School, Rutgers, The State University of New Jersey, 185 South Orange Avenue, Newark, NJ 07103, USA.
- 5Luxembourg Centre for Systems Biomedicine, 7 Avenue des Hauts Fourneaux, Esch sur Alzette 4362, Luxembourg.
- 6National Center for Microscopy and Imaging Research, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
- 7Department of Physics, Humboldt University Berlin, Newtonstraße 15, Berlin 12489, Germany.
- ↵*Corresponding authors. E-mail: martin.falcke{at}mdc-berlin.de (M.F.); cwt1000{at}cam.ac.uk (C.W.T.)
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Science Signaling 24 Jun 2014:
Vol. 7, Issue 331, pp. ra59
DOI: 10.1126/scisignal.2005237
Vol. 7, Issue 331, pp. ra59
DOI: 10.1126/scisignal.2005237
Kevin Thurley
1Mathematical Cell Physiology, Max Delbrück Center for Molecular Medicine, Robert Rössle Straße 10, Berlin 13125, Germany.
2Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK.
3Institute for Theoretical Biology, Charité-Universitätsmedizin Berlin, Invalidenstraße 43, Berlin 10115, Germany.
Stephen C. Tovey
2Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK.
Gregor Moenke
1Mathematical Cell Physiology, Max Delbrück Center for Molecular Medicine, Robert Rössle Straße 10, Berlin 13125, Germany.
Victoria L. Prince
4Department of Pharmacology and Physiology, New Jersey Medical School, Rutgers, The State University of New Jersey, 185 South Orange Avenue, Newark, NJ 07103, USA.
Abha Meena
2Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK.
Andrew P. Thomas
4Department of Pharmacology and Physiology, New Jersey Medical School, Rutgers, The State University of New Jersey, 185 South Orange Avenue, Newark, NJ 07103, USA.
Alexander Skupin
5Luxembourg Centre for Systems Biomedicine, 7 Avenue des Hauts Fourneaux, Esch sur Alzette 4362, Luxembourg.
6National Center for Microscopy and Imaging Research, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Colin W. Taylor
2Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK.
Martin Falcke
1Mathematical Cell Physiology, Max Delbrück Center for Molecular Medicine, Robert Rössle Straße 10, Berlin 13125, Germany.
7Department of Physics, Humboldt University Berlin, Newtonstraße 15, Berlin 12489, Germany.
