Contents
Vol 7, Issue 332
Contents
Research Articles
- Hedgehog induces formation of PKA-Smoothened complexes to promote Smoothened phosphorylation and pathway activation
The secreted protein Hedgehog stimulates switching of kinase-substrate protein complexes to regulate gene expression.
- Exosomes from bone marrow mesenchymal stem cells contain a microRNA that promotes dormancy in metastatic breast cancer cells
The bone marrow delivers dormancy signals in exosomes to metastatic cancer cells.
Perspective
- A Unified Nomenclature and Amino Acid Numbering for Human PTEN
With the discovery of an isoform based on an alternative translation start site, PTEN nomenclature needs an update.
Review
- Transcriptional regulation of the stress response by mTOR
The kinase mTOR may have a greater role in the cellular response to various stresses than currently appreciated.
Podcast
- Science Signaling Podcast: 1 July 2014
Exosomes released by bone marrow mesenchymal stem cells promote dormancy of metastatic breast cancer cells.
Editors' Choice
- Cycling Down Glucose Concentrations
Insulin signaling triggers the suppression of hepatic gluconeogenesis by cyclin D1 and CDK4 in a cell cycle–independent manner.
- PKR, Not Just for Infected Cells
A kinase involved in the antiviral response also regulates the cell cycle.
- Alternatively Spliced into an Inhibitor
A soluble form of a cytokine receptor subunit secreted by T cells blocks cytokine signaling and increases inflammation.
- How Hawkmoths Sniff Out a Flower
Moths find flowers by building an odor map in their antennal lobes.
- Feeling No Pain
Mycobacteria secrete a toxin that acts on angiotensin receptors to inhibit pain.
- An Old Drug Knows New Anticancer Tricks
Inhibition of cyclooxygenase-2 (COX-2) inhibits angiogenesis, suppresses tumor growth, and augments the effects of traditional angiogenesis inhibitors.
