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Abstract
This Podcast features an interview with Takahiro Ochiya, senior author of a Research Article that appears in the 1 July 2014 issue of Science Signaling, about a mechanism by which metastatic breast cancer cells can acquire dormancy in the bone. Even after the primary tumor is eradicated, breast cancer can recur long after treatment, often at secondary sites such as bone and lung. Metastatic breast cancer cells can remain dormant in the bone for many years before resuming rapid proliferation and giving rise to secondary tumors. How cancer cells acquire dormancy in the bone marrow niche has not been clear. Ono et al. report that bone marrow–derived mesenchymal stem cells released exosomes that promoted dormancy of metastatic breast cancer stem cells. These exosomes contained a microRNA (miR-23b) that reduced cell proliferation and motility when the exosomes were taken up by the cancer cells.
