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Abstract
This Podcast features an interview with Ted Young, senior author of a Research Article that appears in the 8 July 2014 issue of Science Signaling, about a kinase that prevents mRNA decay in yeast. Glucose is the preferred carbon source for yeast, but, in the absence of glucose, the cells can change their metabolism to utilize other carbon sources. Glucose deprivation causes activation of the serine-threonine kinase Snf1, which triggers changes in gene expression that allow the cells to metabolize other carbon sources. In addition to promoting gene transcription, Snf1 has also been implicated in inhibiting the decay of transcripts encoding proteins that help cells survive without glucose. A group led by Ted Young used phosphoproteomic analysis to identify proteins downstream of Snf1 that are involved in messenger RNA metabolism. Braun et al. identified the exoribouclease Xrn1 as required for stabilization of Snf1-dependent transcripts in the absence of glucose and for the degradation of these transcripts upon feeding with glucose.
