Contents

Contents

• Research Article

  • The E3 ligase PARC mediates the degradation of cytosolic cytochrome c to promote survival in neurons and cancer cells

    By Vivian Gama, Vijay Swahari, Johanna Schafer, Adam J. Kole, Allyson Evans, Yolanda Huang, Anna Cliffe, Brian Golitz, Noah Sciaky, Xin-Hai Pei, Yue Xiong, Mohanish Deshmukh

    Science Signaling15 Jul 2014 : ra67 Full AccessRestricted Access

    Neurons and cancer cells rely on the protein PARC to survive mitochondrial stress.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF
    • Supplementary Materials

• Research Resource

  • Rapidly rendering cells phagocytic through a cell surface display technique and concurrent Rac activation

    By Hiroki Onuma, Toru Komatsu, Makoto Arita, Kenjiro Hanaoka, Tasuku Ueno, Takuya Terai, Tetsuo Nagano, Takanari Inoue

    Science Signaling15 Jul 2014 : rs4 Full AccessRestricted Access

    A method to enforce the cell surface display of molecules of interest can change cellular function.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF
    • Supplementary Materials

• Perspective

  • Killing the Killer: PARC/CUL9 Promotes Cell Survival by Destroying Cytochrome c

    By Jonathan Lopez, Stephen W. G. Tait

    Science Signaling15 Jul 2014 : pe17 Full AccessRestricted Access

    As an apoptotic suppressor, E3 ligase PARC may be differentially targeted for therapeutic benefit in cancer and neurodegenerative diseases.

    • Abstract
    • Full Text
    • PDF

• Review

  • The WNK-SPAK/OSR1 pathway: Master regulator of cation-chloride cotransporters

    By Dario R. Alessi, Jinwei Zhang, Arjun Khanna, Thomas Hochdörfer, Yuze Shang, Kristopher T. Kahle

    Science Signaling15 Jul 2014 : re3 Full AccessRestricted Access

    A two-tiered kinase cascade is a potentially important therapeutic target for hypertension and neurological diseases of hyperexcitability.

    • Abstract
    • Full Text
    • PDF

• Editors' Choice

  • Combined Treatment for Rett Syndrome

    By Nancy R. Gough

    Science Signaling15 Jul 2014 : ec190 Full AccessRestricted Access

    Treatment with the growth factor IGF1 and the β₂-adrenergic receptor agonist clenbuterol may benefit patients with Rett syndrome.

    • Abstract

  • HO-1 Promotes Unhealthy Obesity

    By Jason D. Berndt

    Science Signaling15 Jul 2014 : ec191 Full AccessRestricted Access

    Heme oxygenase-1 promotes inflammation and insulin resistance in obesity.

    • Abstract

  • Delineating Wnt Pathways in Pain

    By Leslie K. Ferrarelli

    Science Signaling15 Jul 2014 : ec192 Full AccessRestricted Access

    Targeting two branches of Wnt signaling might alleviate pain associated with cancer.

    • Abstract