Contents
Vol 7, Issue 334
Contents
Research Article
- The E3 ligase PARC mediates the degradation of cytosolic cytochrome c to promote survival in neurons and cancer cells
Neurons and cancer cells rely on the protein PARC to survive mitochondrial stress.
Research Resource
- Rapidly rendering cells phagocytic through a cell surface display technique and concurrent Rac activation
A method to enforce the cell surface display of molecules of interest can change cellular function.
Perspective
- Killing the Killer: PARC/CUL9 Promotes Cell Survival by Destroying Cytochrome c
As an apoptotic suppressor, E3 ligase PARC may be differentially targeted for therapeutic benefit in cancer and neurodegenerative diseases.
Review
- The WNK-SPAK/OSR1 pathway: Master regulator of cation-chloride cotransporters
A two-tiered kinase cascade is a potentially important therapeutic target for hypertension and neurological diseases of hyperexcitability.
Editors' Choice
- Combined Treatment for Rett Syndrome
Treatment with the growth factor IGF1 and the β2-adrenergic receptor agonist clenbuterol may benefit patients with Rett syndrome.
- HO-1 Promotes Unhealthy Obesity
Heme oxygenase-1 promotes inflammation and insulin resistance in obesity.
- Delineating Wnt Pathways in Pain
Targeting two branches of Wnt signaling might alleviate pain associated with cancer.