eLetters is an online forum for ongoing peer review. Submission of eLetters are open to all. Please read our Terms of Service before submitting your own eLetter.
- Re: Combined Treatment for Rett Syndrome
The editors wish to alert readers that the original Editors' Choice summary contained an error: In the sentence below, male heterozygous mice were incorrectly stated to have a decrease in the abundance of pCREB:
Analysis of the cerebellum of male Mecp2–/y mice revealed a decrease in activated phosphorylated CREB (pCREB), a transcription factor that stimulates Bdnf expression, and clenbuterol treatment increased the amount of pCREB and Bdnf and Igf1 mRNAs in the cerebellum.
The abundance of pCREB in cerebellum was not different from that in wild-type mouse brain. The sentence has been updated as of 18 August 2014 to read:
Analysis of the cerebellum of male Mecp2–/y mice revealed a decrease in Bdnf expression and protein abundance, and clenbuterol treatment increased the amount of pCREB, the transcription factor that stimulates Bdnf expression, and Bdnf and Igf1 mRNAs in the cerebellum.Competing Interests: None declared.
