Editors' ChoiceMEDICINE

Combined Treatment for Rett Syndrome

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Science Signaling  15 Jul 2014:
Vol. 7, Issue 334, pp. ec190
DOI: 10.1126/scisignal.2005683

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  • Re: Combined Treatment for Rett Syndrome

    The editors wish to alert readers that the original Editors' Choice summary contained an error: In the sentence below, male heterozygous mice were incorrectly stated to have a decrease in the abundance of pCREB:
    Analysis of the cerebellum of male Mecp2–/y mice revealed a decrease in activated phosphorylated CREB (pCREB), a transcription factor that stimulates Bdnf expression, and clenbuterol treatment increased the amount of pCREB and Bdnf and Igf1 mRNAs in the cerebellum.
    The abundance of pCREB in cerebellum was not different from that in wild-type mouse brain. The sentence has been updated as of 18 August 2014 to read:
    Analysis of the cerebellum of male Mecp2–/y mice revealed a decrease in Bdnf expression and protein abundance, and clenbuterol treatment increased the amount of pCREB, the transcription factor that stimulates Bdnf expression, and Bdnf and Igf1 mRNAs in the cerebellum.

    Competing Interests: None declared.