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vol. 7 no. 334 ra67
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History:
- Received March 27, 2014
- Accepted June 23, 2014
- .
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Copyright © 2014, American Association for the Advancement of Science
Research ArticleCell Biology
The E3 ligase PARC mediates the degradation of cytosolic cytochrome c to promote survival in neurons and cancer cells
- Vivian Gama1,2,
- Vijay Swahari1,2,
- Johanna Schafer1,*,
- Adam J. Kole2,
- Allyson Evans2,†,
- Yolanda Huang2,‡,
- Anna Cliffe1,2,
- Brian Golitz3,4,
- Noah Sciaky3,4,
- Xin-Hai Pei5,6,
- Yue Xiong5,6, and
- Mohanish Deshmukh1,2,5,§
- 1Neuroscience Center, University of North Carolina, Chapel Hill, NC 27599, USA.
- 2Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, NC 27599, USA.
- 3UNC RNAi Screening Facility, University of North Carolina, Chapel Hill, NC 27599, USA.
- 4Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27599, USA.
- 5Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.
- 6Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599, USA.
- ↵§Corresponding author. E-mail: mohanish{at}med.unc.edu
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Science Signaling 15 Jul 2014:
Vol. 7, Issue 334, pp. ra67
DOI: 10.1126/scisignal.2005309
Vol. 7, Issue 334, pp. ra67
DOI: 10.1126/scisignal.2005309
Vivian Gama
1Neuroscience Center, University of North Carolina, Chapel Hill, NC 27599, USA.
2Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, NC 27599, USA.
Vijay Swahari
1Neuroscience Center, University of North Carolina, Chapel Hill, NC 27599, USA.
2Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, NC 27599, USA.
Johanna Schafer
1Neuroscience Center, University of North Carolina, Chapel Hill, NC 27599, USA.
Adam J. Kole
2Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, NC 27599, USA.
Allyson Evans
2Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, NC 27599, USA.
Yolanda Huang
2Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, NC 27599, USA.
Anna Cliffe
1Neuroscience Center, University of North Carolina, Chapel Hill, NC 27599, USA.
2Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, NC 27599, USA.
Brian Golitz
3UNC RNAi Screening Facility, University of North Carolina, Chapel Hill, NC 27599, USA.
4Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27599, USA.
Noah Sciaky
3UNC RNAi Screening Facility, University of North Carolina, Chapel Hill, NC 27599, USA.
4Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27599, USA.
Xin-Hai Pei
5Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.
6Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599, USA.
Yue Xiong
5Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.
6Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599, USA.
Mohanish Deshmukh
1Neuroscience Center, University of North Carolina, Chapel Hill, NC 27599, USA.
2Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, NC 27599, USA.
5Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.
