The E3 ligase PARC mediates the degradation of cytosolic cytochrome c to promote survival in neurons and cancer cells

Vivian Gama; Vijay Swahari; Johanna Schafer; Adam J. Kole; Allyson Evans; Yolanda Huang; Anna Cliffe; Brian Golitz; Noah Sciaky; Xin-Hai Pei; Yue Xiong; Mohanish Deshmukh

doi:10.1126/scisignal.2005309

Research ArticleCell Biology

The E3 ligase PARC mediates the degradation of cytosolic cytochrome c to promote survival in neurons and cancer cells

Vivian Gama¹,²,
Vijay Swahari¹,²,
Johanna Schafer¹,*,
Adam J. Kole²,
Allyson Evans²,†,
Yolanda Huang²,‡,
Anna Cliffe¹,²,
Brian Golitz³,⁴,
Noah Sciaky³,⁴,
Xin-Hai Pei⁵,⁶,
Yue Xiong⁵,⁶, and
Mohanish Deshmukh¹,²,⁵,§

¹Neuroscience Center, University of North Carolina, Chapel Hill, NC 27599, USA.
²Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, NC 27599, USA.
³UNC RNAi Screening Facility, University of North Carolina, Chapel Hill, NC 27599, USA.
⁴Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27599, USA.
⁵Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.
⁶Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599, USA.

↵§Corresponding author. E-mail: mohanish{at}med.unc.edu

↵* Present address: Vanderbilt University, Nashville, TN 37232, USA.
↵† Present address: Cell Press, Cambridge, MA 02139, USA.
↵‡ Present address: Department of Anesthesiology, Columbia University Medical Center, New York, NY 10032, USA.

See allHide authors and affiliations

Science Signaling 15 Jul 2014:
Vol. 7, Issue 334, pp. ra67
DOI: 10.1126/scisignal.2005309

Vivian Gama

1Neuroscience Center, University of North Carolina, Chapel Hill, NC 27599, USA.

2Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, NC 27599, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Vijay Swahari

1Neuroscience Center, University of North Carolina, Chapel Hill, NC 27599, USA.

2Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, NC 27599, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Johanna Schafer

1Neuroscience Center, University of North Carolina, Chapel Hill, NC 27599, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Adam J. Kole

2Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, NC 27599, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Allyson Evans

2Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, NC 27599, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Yolanda Huang

2Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, NC 27599, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Anna Cliffe

1Neuroscience Center, University of North Carolina, Chapel Hill, NC 27599, USA.

2Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, NC 27599, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Brian Golitz

3UNC RNAi Screening Facility, University of North Carolina, Chapel Hill, NC 27599, USA.

4Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27599, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Noah Sciaky

3UNC RNAi Screening Facility, University of North Carolina, Chapel Hill, NC 27599, USA.

4Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27599, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Xin-Hai Pei

5Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.

6Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Yue Xiong

5Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.

6Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Mohanish Deshmukh

1Neuroscience Center, University of North Carolina, Chapel Hill, NC 27599, USA.

2Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, NC 27599, USA.

5Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
For correspondence: mohanish@med.unc.edu

Article
Figures & Data
Info & Metrics
eLetters
PDF

eLetters is an online forum for ongoing peer review. Submission of eLetters are open to all. Please read our Terms of Service before submitting your own eLetter.

Submit a Response to This Article

Compose eLetter

Title

Contents

More information about text formats

Plain text

Plain text
No HTML tags allowed.
Web page addresses and e-mail addresses turn into links automatically.
Lines and paragraphs break automatically.

Author Information

Contributors
First name and middle name First or given name, e.g. 'Peter'. Last Name Your last, or family, name, e.g. 'MacMoody'. Email Your email address, e.g. higgs-boson@gmail.com Role / Occupation Your role and/or occupation, e.g. 'Orthopedic Surgeon'. Affiliation Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.

Statement of Competing Interests

Competing interests?

Yes

Please describe the competing interests

CAPTCHA

This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Vertical Tabs

No eLetters have been published for this article.

View Full Text

The E3 ligase PARC mediates the degradation of cytosolic cytochrome c to promote survival in neurons and cancer cells

Plain text

Vertical Tabs

Science Signaling

Article Tools