The E3 ligase PARC mediates the degradation of cytosolic cytochrome c to promote survival in neurons and cancer cells

Vivian Gama; Vijay Swahari; Johanna Schafer; Adam J. Kole; Allyson Evans; Yolanda Huang; Anna Cliffe; Brian Golitz; Noah Sciaky; Xin-Hai Pei; Yue Xiong; Mohanish Deshmukh

doi:10.1126/scisignal.2005309

Research ArticleCell Biology

The E3 ligase PARC mediates the degradation of cytosolic cytochrome c to promote survival in neurons and cancer cells

Vivian Gama¹,²,
Vijay Swahari¹,²,
Johanna Schafer¹,*,
Adam J. Kole²,
Allyson Evans²,†,
Yolanda Huang²,‡,
Anna Cliffe¹,²,
Brian Golitz³,⁴,
Noah Sciaky³,⁴,
Xin-Hai Pei⁵,⁶,
Yue Xiong⁵,⁶, and
Mohanish Deshmukh¹,²,⁵,§

¹Neuroscience Center, University of North Carolina, Chapel Hill, NC 27599, USA.
²Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, NC 27599, USA.
³UNC RNAi Screening Facility, University of North Carolina, Chapel Hill, NC 27599, USA.
⁴Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27599, USA.
⁵Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.
⁶Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599, USA.

↵§Corresponding author. E-mail: mohanish{at}med.unc.edu

↵* Present address: Vanderbilt University, Nashville, TN 37232, USA.
↵† Present address: Cell Press, Cambridge, MA 02139, USA.
↵‡ Present address: Department of Anesthesiology, Columbia University Medical Center, New York, NY 10032, USA.

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Science Signaling 15 Jul 2014:
Vol. 7, Issue 334, pp. ra67
DOI: 10.1126/scisignal.2005309

Vivian Gama

Neuroscience Center, University of North Carolina, Chapel Hill, NC 27599, USA.Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, NC 27599, USA.

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Vijay Swahari

Neuroscience Center, University of North Carolina, Chapel Hill, NC 27599, USA.Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, NC 27599, USA.

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Johanna Schafer

Neuroscience Center, University of North Carolina, Chapel Hill, NC 27599, USA.

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Adam J. Kole

Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, NC 27599, USA.

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Allyson Evans

Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, NC 27599, USA.

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Yolanda Huang

Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, NC 27599, USA.

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Anna Cliffe

Neuroscience Center, University of North Carolina, Chapel Hill, NC 27599, USA.Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, NC 27599, USA.

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Brian Golitz

UNC RNAi Screening Facility, University of North Carolina, Chapel Hill, NC 27599, USA.Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27599, USA.

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Noah Sciaky

UNC RNAi Screening Facility, University of North Carolina, Chapel Hill, NC 27599, USA.Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27599, USA.

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Xin-Hai Pei

Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599, USA.

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Yue Xiong

Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599, USA.

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Mohanish Deshmukh

Neuroscience Center, University of North Carolina, Chapel Hill, NC 27599, USA.Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, NC 27599, USA.Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.

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For correspondence: mohanish@med.unc.edu

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The E3 ligase PARC mediates the degradation of cytosolic cytochrome c to promote survival in neurons and cancer cells

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