Research ResourceTechniques

Rapidly rendering cells phagocytic through a cell surface display technique and concurrent Rac activation

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Science Signaling  15 Jul 2014:
Vol. 7, Issue 334, pp. rs4
DOI: 10.1126/scisignal.2005123

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Turning Cells into Garbage Collectors

Dead cells must be rapidly consumed by phagocytes, professional garbage-collecting cells, to protect other cells or tissue from injury. Under certain disease states, however, the phagocytes become overwhelmed and could do with some help. Onuma et al. manipulated cells that are not natural phagocytes with a cell surface display technique so that the engineered cells could specifically bind to and consume dying cells. This technique might be used therapeutically to engineer cells to help the body to remove undesirable targets.

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