Rapidly rendering cells phagocytic through a cell surface display technique and concurrent Rac activation

Hiroki Onuma; Toru Komatsu; Makoto Arita; Kenjiro Hanaoka; Tasuku Ueno; Takuya Terai; Tetsuo Nagano; Takanari Inoue

doi:10.1126/scisignal.2005123

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Rapidly rendering cells phagocytic through a cell surface display technique and concurrent Rac activation

Hiroki Onuma¹,
Toru Komatsu¹,²,*,
Makoto Arita¹,†,
Kenjiro Hanaoka¹,
Tasuku Ueno¹,
Takuya Terai¹,
Tetsuo Nagano³, and
Takanari Inoue²,⁴,⁵,*

¹Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033 Japan.
²Precursory Research for Embryonic Science and Technology Investigator, Japan Science and Technology Agency, 4-1-8 Honcho Kawaguchi, Saitama 332-0012, Japan.
³Open Innovation Center for Drug Discovery, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
⁴Department of Cell Biology, School of Medicine, Johns Hopkins University, 855 North Wolfe Street, Baltimore, MD 21205, USA.
⁵Center for Cell Dynamics, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.

↵*Corresponding author. E-mail: tkomatsu{at}mol.f.u-tokyo.ac.jp (T.K.); jctinoue{at}jhmi.edu (T.I.)

↵† Present address: RIKEN Center for Integrative Medical Sciences, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama City, Kanagawa 230-0045, Japan.

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Science Signaling 15 Jul 2014:
Vol. 7, Issue 334, pp. rs4
DOI: 10.1126/scisignal.2005123

Hiroki Onuma

1Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033 Japan.

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Toru Komatsu

1Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033 Japan.

2Precursory Research for Embryonic Science and Technology Investigator, Japan Science and Technology Agency, 4-1-8 Honcho Kawaguchi, Saitama 332-0012, Japan.

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For correspondence: tkomatsu@mol.f.u-tokyo.ac.jp jctinoue@jhmi.edu

Makoto Arita

1Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033 Japan.

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Kenjiro Hanaoka

1Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033 Japan.

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Tasuku Ueno

1Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033 Japan.

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Takuya Terai

1Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033 Japan.

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Tetsuo Nagano

3Open Innovation Center for Drug Discovery, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

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Takanari Inoue

2Precursory Research for Embryonic Science and Technology Investigator, Japan Science and Technology Agency, 4-1-8 Honcho Kawaguchi, Saitama 332-0012, Japan.

4Department of Cell Biology, School of Medicine, Johns Hopkins University, 855 North Wolfe Street, Baltimore, MD 21205, USA.

5Center for Cell Dynamics, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.

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For correspondence: tkomatsu@mol.f.u-tokyo.ac.jp jctinoue@jhmi.edu

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