Contents
Vol 7, Issue 335
Contents
Research Articles
- REDD1 enhances protein phosphatase 2A–mediated dephosphorylation of Akt to repress mTORC1 signaling
REDD1 targets a phosphatase to the kinase Akt, thereby changing the substrate specificity of Akt and inhibiting mTORC1 activity.
- The membrane protein Pannexin1 forms two open-channel conformations depending on the mode of activation
Pannexin1 can be stimulated to form either a high- or a low-conductance channel with distinct ionic permeabilities.
Research Resource
- Time-resolved dissection of early phosphoproteome and ensuing proteome changes in response to TGF-β
Proteomics analysis of TGF-β signaling in keratinocytes reveals widespread changes in protein phosphorylation and abundance.
Perspective
- Neuronal STIMulation at Rest
Complex interplay between channels and pumps in the endoplasmic reticulum and the plasma membrane controls calcium homeostasis in neurons.
Editors' Choice
- Two-for-One Suppression of the Antiviral Response
The V protein of measles virus suppresses the antiviral response by two distinct mechanisms that target protein phosphatase 1.
- Retrograde Flow for Forward Cell Migration
Retrograde flow of adherens junctions enables collectively migrating cells to maintain cohesion and requires polarized regulation of cadherin-catenin interactions.
- How the Worm Changes Its Tastes
Calsyntenin-dependent activation of insulin-PI3K signaling in the synaptic region governs associative learning.
- Taking a Check on Chromosome Spacing
A mitotic spindle midzone-associated Aurora B gradient monitors chromosome separation during cell division.
- Evolving from an Enzyme and into a Regulator
Alternative splicing of aminoacyl transfer RNA synthetases ablates the catalytic domain to yield diverse alternative functions.
- Switching Partners by Phosphorylation
Crosstalk between MAPK and Hippo pathways is mediated by phosphorylation-regulated competition for interaction with the kinase RAF-1.
