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Time-resolved dissection of early phosphoproteome and ensuing proteome changes in response to TGF-β

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Science Signaling  22 Jul 2014:
Vol. 7, Issue 335, pp. rs5
DOI: 10.1126/scisignal.2004856

In Deep with TGF-β Signaling

TGF-β signaling regulates the epithelial-to-mesenchymal transition (EMT), which is associated with increased migratory behavior, in various tissues during development and in cancer. D’Souza et al. analyzed temporal changes in the proteome and phosphoproteome of cultured keratinocytes undergoing TGF-β–induced EMT. They identified thousands of changes in proteins involved in many cellular processes, including the cell cycle, cell motility, DNA repair, and vesicle transport. This comprehensive analysis represents a vast resource of data for researchers interested in TGF-β–dependent biology.

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