Contents
Vol 7, Issue 337
Contents
Research Articles
- Dimerization of the kinase ARAF promotes MAPK pathway activation and cell migration
Targeting the RAF kinase dimerization may overcome resistance to current RAF inhibitors and prevent cancer metastasis.
- Calmodulin and PI(3,4,5)P3 cooperatively bind to the Itk pleckstrin homology domain to promote efficient calcium signaling and IL-17A production
Calcium and lipids stimulate the kinase Itk through the same domain to promote proinflammatory T cell signaling.
Review
- The Hippo signal transduction network in skeletal and cardiac muscle
The Hippo pathway plays a role in muscle and heart development, regeneration, and disease.
Podcast
- Science Signaling Podcast: 5 August 2014
The kinase ARAF is required for MAPK pathway activation and cell migration induced by BRAF inhibitors.
Editors' Choice
- Complex Roles for Hedgehog Signaling in Pancreatic Cancer
Inhibition of Hedgehog signaling enhances the growth of pancreatic cancer in genetic mouse models.
- Going Nuclear with EGFR
Nuclear EGFR promotes posttranslational modifications of histone H4 that stimulate DNA synthesis and repair.
- Remembering Spatial Organization Requires Targeted Translation
Synaptic plasticity that promotes spatial memory is mediated by a specific protein synthesis pathway in mice.
- Getting the Right Receptors to the Synapse
Long and short isoforms of Punctin serve as landmarks for proper clustering of postsynaptic excitatory and inhibitory receptors on muscle cells.
- A Neuropeptide Kills Patients’ Motivation
The effort mice are willing to put into obtaining a reward is decreased in inflammatory and neuropathic models of pain.
- How Do Fingers Know Where to Grow?
Modeling and experiments reveal how limb digits are patterned by three components.
- Parasites Make It Hard to Fight Viruses
Coinfection with intestinal parasites leads to altered antiviral immunity in mice.
