Editors' ChoiceCancer

Going Nuclear with EGFR

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Science Signaling  05 Aug 2014:
Vol. 7, Issue 337, pp. ec205
DOI: 10.1126/scisignal.2005761

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  • Re: Going Nuclear with EGFR

    The recent paper by Chou et al. (Dev. Cell 2014), highlighted in Science Signaling, describes the phosphorylation of Tyr72 on histone H4 by the EGF receptor (EGFR).  The authors propose that EGFR enters the nucleus and phosphorylates H4.  We examined the crystal structure of the nucleosome core particle Ncp147 (PDB ID: 1KX5), and found that – surprisingly – this residue is completely buried.  It directly faces histone H2B near the center of the octamer core.  Given the stability of this structure, it is very difficult to envision how a tyrosine kinase would gain access to the residue in order to phosphorylate it.

    Competing Interests: None declared.