Contents
Vol 7, Issue 338
Contents
Research Articles
- Targeting aPKC disables oncogenic signaling by both the EGFR and the proinflammatory cytokine TNFα in glioblastoma
Targeting a kinase common to both the EGFR and TNFα signaling pathways may prevent drug resistance in glioblastoma.
- Type IV collagen is an activating ligand for the adhesion G protein–coupled receptor GPR126
Type IV collagen activates the cell surface receptor GPR126, an orphan receptor that is crucial for Schwann cell differentiation and myelination.
- The tyrosine kinase Lyn limits the cytokine responsiveness of plasma cells to restrict their accumulation in mice
A nonreceptor tyrosine kinase inhibits cytokine signaling to prevent the persistence of antibody-secreting cells.
Perspective
- Lipocalin 2 as a Membrane-Reorganizing Agent
A protein that binds to diverse hydrophobic substrates reorganizes the sperm plasma membrane in preparation for fertilization.
Podcast
- Science Signaling Podcast: 12 August 2014
The orphan receptor GPR126 is activated by binding to type IV collagen.
Editors' Choice
- Going a Notch More Beige
The “browning” of white adipose tissue is induced upon suppression of Notch signaling.
- Timing Responses to Infection
Circadian rhythms in lung epithelial cells affect neutrophil recruitment in response to infection.
- Bad Cholesterol: Bad for Bacteria, Too?
Antiviral immune responses induce an oxysterol that suppresses interleukin-1–mediated inflammation.
- How to Plumb the Root Is the Problem
A genetic network integrates hormonal inputs to establish a stable tissue pattern within a growing plant tissue.
- Biofilm Positive Feedback
A two-component tyrosine kinase mediates positive feedback of exopolysaccharide production during biofilm formation.
