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vol. 7 no. 338 ra75
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- Received February 18, 2014
- Accepted July 23, 2014
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Copyright © 2014, American Association for the Advancement of Science
Research ArticleCancer
Targeting aPKC disables oncogenic signaling by both the EGFR and the proinflammatory cytokine TNFα in glioblastoma
- Yael Kusne1,2,*,
- Eugenio A. Carrera-Silva3,*,
- Anthony S. Perry4,
- Elisabeth J. Rushing5,†,
- Edward K. Mandell6,
- Justin D. Dietrich7,‡,
- Andrea E. Errasti3,
- Daniel Gibbs8,
- Michael E. Berens9,
- Joseph C. Loftus10,
- Christopher Hulme7,
- Weiwei Yang11,
- Zhimin Lu11,
- Kenneth Aldape11,
- Nader Sanai1,2,
- Carla V. Rothlin3,§, and
- Sourav Ghosh1,2,6,9,§
- 1Neuroscience Graduate Program, Arizona State University, Phoenix, AZ 85287, USA.
- 2Barrow Brain Tumor Research Center, Barrow Neurological Institute, Phoenix, AZ 85013, USA.
- 3Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.
- 4Department of Pathology, Banner MD Anderson Cancer Center, Gilbert, AZ 85234, USA.
- 5Armed Forces Institute of Pathology, Washington, DC 20306–0003, USA.
- 6Department of Neurology, Yale University School of Medicine, New Haven, CT 06511, USA.
- 7Bio5OV, The University of Arizona, Oro Valley, AZ 85737, USA.
- 8Department of Neurosciences, University of California, San Diego, San Diego, CA 92093, USA.
- 9Translational Genomics Research Institute (TGen), Phoenix, AZ 85004, USA.
- 10Mayo Clinic Arizona, Scottsdale, AZ 85259, USA.
- 11MD Anderson Cancer Center, Houston, TX 77030, USA.
- ↵§Corresponding author. E-mail: carla.rothlin{at}yale.edu (C.V.R.); sourav.ghosh{at}yale.edu (S.G.)
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Science Signaling 12 Aug 2014:
Vol. 7, Issue 338, pp. ra75
DOI: 10.1126/scisignal.2005196
Vol. 7, Issue 338, pp. ra75
DOI: 10.1126/scisignal.2005196
Yael Kusne
1Neuroscience Graduate Program, Arizona State University, Phoenix, AZ 85287, USA.
2Barrow Brain Tumor Research Center, Barrow Neurological Institute, Phoenix, AZ 85013, USA.
Eugenio A. Carrera-Silva
3Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.
Anthony S. Perry
4Department of Pathology, Banner MD Anderson Cancer Center, Gilbert, AZ 85234, USA.
Elisabeth J. Rushing
5Armed Forces Institute of Pathology, Washington, DC 20306–0003, USA.
Edward K. Mandell
6Department of Neurology, Yale University School of Medicine, New Haven, CT 06511, USA.
Justin D. Dietrich
7Bio5OV, The University of Arizona, Oro Valley, AZ 85737, USA.
Andrea E. Errasti
3Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.
Daniel Gibbs
8Department of Neurosciences, University of California, San Diego, San Diego, CA 92093, USA.
Michael E. Berens
9Translational Genomics Research Institute (TGen), Phoenix, AZ 85004, USA.
Joseph C. Loftus
10Mayo Clinic Arizona, Scottsdale, AZ 85259, USA.
Christopher Hulme
7Bio5OV, The University of Arizona, Oro Valley, AZ 85737, USA.
Weiwei Yang
11MD Anderson Cancer Center, Houston, TX 77030, USA.
Zhimin Lu
11MD Anderson Cancer Center, Houston, TX 77030, USA.
Kenneth Aldape
11MD Anderson Cancer Center, Houston, TX 77030, USA.
Nader Sanai
1Neuroscience Graduate Program, Arizona State University, Phoenix, AZ 85287, USA.
2Barrow Brain Tumor Research Center, Barrow Neurological Institute, Phoenix, AZ 85013, USA.
Carla V. Rothlin
3Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.
Sourav Ghosh
1Neuroscience Graduate Program, Arizona State University, Phoenix, AZ 85287, USA.
2Barrow Brain Tumor Research Center, Barrow Neurological Institute, Phoenix, AZ 85013, USA.
6Department of Neurology, Yale University School of Medicine, New Haven, CT 06511, USA.
9Translational Genomics Research Institute (TGen), Phoenix, AZ 85004, USA.
