Research ArticleCancer
Targeting aPKC disables oncogenic signaling by both the EGFR and the proinflammatory cytokine TNFα in glioblastoma
- Yael Kusne1,2,*,
- Eugenio A. Carrera-Silva3,*,
- Anthony S. Perry4,
- Elisabeth J. Rushing5,†,
- Edward K. Mandell6,
- Justin D. Dietrich7,‡,
- Andrea E. Errasti3,
- Daniel Gibbs8,
- Michael E. Berens9,
- Joseph C. Loftus10,
- Christopher Hulme7,
- Weiwei Yang11,
- Zhimin Lu11,
- Kenneth Aldape11,
- Nader Sanai1,2,
- Carla V. Rothlin3,§, and
- Sourav Ghosh1,2,6,9,§
- 1Neuroscience Graduate Program, Arizona State University, Phoenix, AZ 85287, USA.
- 2Barrow Brain Tumor Research Center, Barrow Neurological Institute, Phoenix, AZ 85013, USA.
- 3Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.
- 4Department of Pathology, Banner MD Anderson Cancer Center, Gilbert, AZ 85234, USA.
- 5Armed Forces Institute of Pathology, Washington, DC 20306–0003, USA.
- 6Department of Neurology, Yale University School of Medicine, New Haven, CT 06511, USA.
- 7Bio5OV, The University of Arizona, Oro Valley, AZ 85737, USA.
- 8Department of Neurosciences, University of California, San Diego, San Diego, CA 92093, USA.
- 9Translational Genomics Research Institute (TGen), Phoenix, AZ 85004, USA.
- 10Mayo Clinic Arizona, Scottsdale, AZ 85259, USA.
- 11MD Anderson Cancer Center, Houston, TX 77030, USA.
- ↵§Corresponding author. E-mail: carla.rothlin{at}yale.edu (C.V.R.); sourav.ghosh{at}yale.edu (S.G.)
-
↵* These authors contributed equally to this work.
-
↵† Present address: University Hospital Zurich, 8091 Zurich, Switzerland.
-
↵‡ Present address: AbbVie, North Chicago, IL 60064, USA.
See allHide authors and affiliations
Science Signaling 12 Aug 2014:
Vol. 7, Issue 338, pp. ra75
DOI: 10.1126/scisignal.2005196