The tyrosine kinase Lyn limits the cytokine responsiveness of plasma cells to restrict their accumulation in mice

Simona Infantino; Sarah A. Jones; Jennifer A. Walker; Mhairi J. Maxwell; Amanda Light; Kristy O’Donnell; Evelyn Tsantikos; Victor Peperzak; Toby Phesse; Matthias Ernst; Fabienne Mackay; Margaret L. Hibbs; Kirsten A. Fairfax; David M. Tarlinton

doi:10.1126/scisignal.2005105

Research ArticleImmunology

The tyrosine kinase Lyn limits the cytokine responsiveness of plasma cells to restrict their accumulation in mice

Simona Infantino¹,²,*,
Sarah A. Jones¹,²,³,*,
Jennifer A. Walker¹,²,
Mhairi J. Maxwell⁴,
Amanda Light¹,²,
Kristy O’Donnell¹,²,
Evelyn Tsantikos⁴,
Victor Peperzak¹,²,
Toby Phesse¹,²,
Matthias Ernst¹,²,
Fabienne Mackay⁴,
Margaret L. Hibbs⁴,
Kirsten A. Fairfax¹,²,⁴,*, and
David M. Tarlinton¹,²,*,†

¹The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia.
²Department of Experimental Medicine, University of Melbourne, Parkville, Victoria 3052, Australia.
³Centre for Inflammatory Diseases, Southern Clinical School, Monash Medical Centre, Clayton, Victoria 3800, Australia.
⁴Department of Immunology, Alfred Medical Research and Education Precinct, Monash University, Commercial Road, Melbourne, Victoria 3004, Australia.

↵†Corresponding author. E-mail: tarlinton{at}wehi.edu.au

↵* These authors contributed equally to this work.

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Science Signaling 12 Aug 2014:
Vol. 7, Issue 338, pp. ra77
DOI: 10.1126/scisignal.2005105

Simona Infantino

1The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia.

2Department of Experimental Medicine, University of Melbourne, Parkville, Victoria 3052, Australia.

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Sarah A. Jones

1The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia.

2Department of Experimental Medicine, University of Melbourne, Parkville, Victoria 3052, Australia.

3Centre for Inflammatory Diseases, Southern Clinical School, Monash Medical Centre, Clayton, Victoria 3800, Australia.

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Jennifer A. Walker

1The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia.

2Department of Experimental Medicine, University of Melbourne, Parkville, Victoria 3052, Australia.

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Mhairi J. Maxwell

4Department of Immunology, Alfred Medical Research and Education Precinct, Monash University, Commercial Road, Melbourne, Victoria 3004, Australia.

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Amanda Light

1The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia.

2Department of Experimental Medicine, University of Melbourne, Parkville, Victoria 3052, Australia.

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Kristy O’Donnell

1The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia.

2Department of Experimental Medicine, University of Melbourne, Parkville, Victoria 3052, Australia.

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Evelyn Tsantikos

4Department of Immunology, Alfred Medical Research and Education Precinct, Monash University, Commercial Road, Melbourne, Victoria 3004, Australia.

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Victor Peperzak

1The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia.

2Department of Experimental Medicine, University of Melbourne, Parkville, Victoria 3052, Australia.

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Toby Phesse

1The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia.

2Department of Experimental Medicine, University of Melbourne, Parkville, Victoria 3052, Australia.

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Matthias Ernst

1The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia.

2Department of Experimental Medicine, University of Melbourne, Parkville, Victoria 3052, Australia.

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Fabienne Mackay

4Department of Immunology, Alfred Medical Research and Education Precinct, Monash University, Commercial Road, Melbourne, Victoria 3004, Australia.

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Margaret L. Hibbs

4Department of Immunology, Alfred Medical Research and Education Precinct, Monash University, Commercial Road, Melbourne, Victoria 3004, Australia.

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Kirsten A. Fairfax

1The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia.

2Department of Experimental Medicine, University of Melbourne, Parkville, Victoria 3052, Australia.

4Department of Immunology, Alfred Medical Research and Education Precinct, Monash University, Commercial Road, Melbourne, Victoria 3004, Australia.

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David M. Tarlinton

1The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia.

2Department of Experimental Medicine, University of Melbourne, Parkville, Victoria 3052, Australia.

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For correspondence: tarlinton@wehi.edu.au

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The tyrosine kinase Lyn limits the cytokine responsiveness of plasma cells to restrict their accumulation in mice

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