Contents
Vol 7, Issue 339
Contents
Research Articles
- The ErbB4 CYT2 variant protects EGFR from ligand-induced degradation to enhance cancer cell motility
Dimerization of EGFR with an ErbB4 receptor variant increases growth factor–induced migration of breast cancer cells.
- Macromolecular assembly of the adaptor SLP-65 at intracellular vesicles in resting B cells
Optimal B cell activation requires the recruitment of a vesicle-associated adaptor protein to the B cell receptor complex.
- Manipulation of receptor oligomerization as a strategy to inhibit signaling by TNF superfamily members
A three-in-one cytokine engineered to bind to its receptor with high affinity, but prevent receptor activation, may be an effective therapy for osteoporosis.
Perspective
- Outflanking RANK with a Designer Antagonist Cytokine
A single-chain fusion protein of cytokine subunits with opposing affinities for their receptor acts as an effective receptor antagonist.
Podcast
- Science Signaling Podcast: 19 August 2014
Atypical protein kinase C is a promising target for treating glioblastoma.
Editors' Choice
- How Ebola Shuts Down Antiviral Signaling
An Ebola virus protein selectively inhibits nuclear import of STAT1 to block interferon-induced antiviral responses.
- Where and How Chloroquine Fights Cancer
Chloroquine activates Notch signaling in endothelial cells to promote normalization of tumor-associated vessels.
- Synchronizing Metabolism, Physiology, and Behavior Through mTORC1 and FGF21
Liver glutamine metabolism stimulates production of FGF21 to link metabolism with organismal physiology and behavior.
- No Blood Cells Without Cyclin D
Conditional knockout in adult mice of D-type cyclins results in complete loss of hematopoietic cells.
- TRAF3 Restrains Production of Tregs
Signaling by the interleukin-2 receptor in regulatory T cell precursors is inhibited by the adaptor protein TRAF3.
- Defender of Fertility
Human β-defensin 1 plays a dual role in defending male fertility by promoting both the motility of sperm and its bactericidal activity.
- Epigenetics Direct Transdifferentiation
Stepwise modifications to histones ensure efficient and reliable cell conversions in Caenorhabditis elegans.
- Factor in Oocyte Assists Reprogramming
Human oocyte reprogramming of the somatic nucleus involves histone chaperone ASF1A.
- A Leg Up for Transplant
Tacrolimus-encapsulated hydrogels improve long-term survival of a vascularized composite allograft.
- Toward an “Artificial Cell” on a Chip
DNA-driven biochemical reactions on a fabricated silicon chip recreate protein gradients and oscillations.
