Research ArticleImmunology

Macromolecular assembly of the adaptor SLP-65 at intracellular vesicles in resting B cells

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Science Signaling  19 Aug 2014:
Vol. 7, Issue 339, pp. ra79
DOI: 10.1126/scitranslmed.2005104

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Vesicular Delivery of an Adaptor in B Cells

Stimulation of a complex and ordered network of protein-protein interactions is necessary for B cell activation and antibody-mediated immunity. Engelke et al. found a role for protein-lipid interactions in this process. The cytosolic adaptor protein SLP-65 was associated with intracellular vesicles in unstimulated B cells and required residues in its N terminus for this vesicular association. Activation of the B cell receptor stimulated the translocation of vesicles carrying SLP-65 to the receptor complex to ensure optimal B cell signaling.