Research ArticlesNeuroscience

Semaphorin 3A activates the guanosine triphosphatase Rab5 to promote growth cone collapse and organize callosal axon projections

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Science Signaling  26 Aug 2014:
Vol. 7, Issue 340, pp. ra81
DOI: 10.1126/scisignal.2005334

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Endocytosis Is Necessary for Axon Collapse

In the brain, the corpus callosum is a bundle of neural tissue that enables communication between the right and left hemispheres. Abnormal development of the corpus callosum is associated with congenital birth defects. Neuronal connectivity is guided by attraction and repulsion signals that, respectively, induce the growth or collapse of neuronal projections called axons. Wu et al. investigated pathways activated by Sema3A, a repulsive axon guidance signal, during the development of the mouse corpus callosum. They identified a pathway involving internalization of the membrane from the surface that is necessary for the collapse signal induced by Sema3A.

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